QuickView for apoA-II (gene)
- Gene Symbol:
- APOA2
Homo sapiens - Full name:
- apolipoprotein A2
- Synonyms:
- Apo-AII, ApoA-II, apoAII, apolipoprotein A-II
- Genomic Location:
- Chr 1: 159458707-159460042
- Description:
-
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1q23.3
GO Molecular Function
enzyme activator activity | cation binding | phosphatidylcholine-sterol O-acyltransferase activator activity | protein-containing complex binding | lipoprotein particle receptor binding | lipid binding | sterol binding | enzyme inhibitor activity | signaling receptor binding | phospholipid binding | cholesterol transporter activity | alcohol binding | molecular function regulator | lipoprotein particle binding | anion binding | phosphatidylcholine binding | lipase inhibitor activity | transporter activity | identical protein binding | protein heterodimerization activity | high-density lipoprotein particle receptor binding | sterol transporter activity | ion binding | organic cyclic compound binding | cholesterol binding | apolipoprotein receptor binding | high-density lipoprotein particle binding | protein binding | protein homodimerization activity | protein dimerization activity | enzyme regulator activity | steroid binding | heat shock protein binding | lipid transporter activity | small molecule binding
GO Biological Process
high-density lipoprotein particle clearance | negative regulation of cholesterol transporter activity | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | extracellular structure organization | negative regulation of peptide secretion | regulation of cholesterol transport | enzyme activator activity | regulation of localization | lipid transport | negative regulation of lipase activity | positive regulation of lipid catabolic process | peptidyl-amino acid modification | protein oxidation | establishment of localization | regulation of immune system process | response to hormone | negative regulation of cellular process | defense response | response to drug | organophosphate catabolic process | protein-lipid complex assembly | negative regulation of protein secretion | phospholipid metabolic process | regulation of lipid transport | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | regulation of cytokine biosynthetic process | localization | phosphatidylcholine-sterol O-acyltransferase activator activity | triglyceride metabolic process | anion transport | regulation of digestive system process | macromolecule localization | negative regulation of secretion | acylglycerol catabolic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of establishment of protein localization | interspecies interaction between organisms | regeneration | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | regulation of metabolic process | negative regulation of cytokine secretion | catabolic process | organic cyclic compound metabolic process | cellular component organization | cellular lipid metabolic process | peptidyl-methionine modification | regulation of peptide secretion | response to stimulus | enzyme inhibitor activity | negative regulation of protein transport | positive regulation of protein metabolic process | response to stress | phosphatidylcholine biosynthetic process | chylomicron assembly | alcohol metabolic process | diacylglycerol catabolic process | regulation of plasma lipoprotein particle levels | sterol homeostasis | cholesterol homeostasis | response to glucose | positive regulation of cytokine biosynthetic process | negative regulation of transporter activity | organic hydroxy compound transport | regulation of cholesterol esterification | cholesterol transporter activity | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | cellular component assembly | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | regulation of steroid metabolic process | molecular function regulator | organic hydroxy compound metabolic process | retinoid metabolic process | system development | nitrogen compound metabolic process | negative regulation of secretion by cell | regulation of interleukin-8 biosynthetic process | regulation of protein stability | multicellular organism development | negative regulation of catalytic activity | regulation of intestinal cholesterol absorption | phosphorus metabolic process | negative regulation of lipid catabolic process | regulation of catalytic activity | lipid metabolic process | regulation of intestinal absorption | regulation of cholesterol transporter activity | organic substance transport | response to lipid | organophosphate metabolic process | negative regulation of cytokine production | positive regulation of cellular metabolic process | phospholipid biosynthetic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | lipase inhibitor activity | response to corticosteroid | phospholipid catabolic process | positive regulation of steroid metabolic process | biosynthetic process | sterol transporter activity | sterol transport | plasma lipoprotein particle assembly | negative regulation of immune response | organic anion transport | lipid biosynthetic process | cholesterol transport | cholesterol efflux | plasma lipoprotein particle clearance | phosphate-containing compound metabolic process | response to estrogen | regulation of cellular metabolic process | cellular lipid catabolic process | regulation of lipid catabolic process | lipoprotein metabolic process | inflammatory response | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of cholesterol esterification | homeostatic process | response to monosaccharide | reverse cholesterol transport | plasma lipoprotein particle remodeling | glycerolipid metabolic process | viral process | regulation of cholesterol import | neutral lipid catabolic process | positive regulation of molecular function | regulation of cytokine secretion | phospholipid transport | negative regulation of lipid transport | protein-containing complex assembly | diacylglycerol metabolic process | protein metabolic process | regulation of establishment of protein localization | response to organic substance | neutral lipid metabolic process | glycerophospholipid biosynthetic process | chylomicron remodeling | phospholipid efflux | anatomical structure development | negative regulation of lipid metabolic process | metabolic process | lipid localization | cholesterol metabolic process | oxidation-reduction process | regulation of cytokine secretion involved in immune response | high-density lipoprotein particle remodeling | chemical homeostasis | regulation of secretion | lipid catabolic process | regulation of intestinal lipid absorption | organic substance metabolic process | animal organ development | regulation of protein secretion | phosphatidylcholine metabolic process | diterpenoid metabolic process | positive regulation of cytokine production | negative regulation of cholesterol transport | negative regulation of very-low-density lipoprotein particle remodeling | steroid metabolic process | negative regulation of molecular function | response to organic cyclic compound | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | high-density lipoprotein particle assembly | isoprenoid metabolic process | glycerophospholipid metabolic process | developmental process | low-density lipoprotein particle remodeling | cellular protein modification process | negative regulation of cytokine secretion involved in immune response | regulation of transport | protein-lipid complex remodeling | negative regulation of hydrolase activity | regulation of lipid metabolic process | triglyceride-rich lipoprotein particle remodeling | positive regulation of metabolic process | positive regulation of interleukin-8 biosynthetic process | lipid transporter activity | positive regulation of lipid metabolic process | ion transport | acute inflammatory response | negative regulation of cholesterol import | cellular metabolic process | regulation of protein localization | response to carbohydrate | response to steroid hormone | acylglycerol metabolic process | lipid homeostasis | regulation of cellular component organization | animal organ regeneration | response to glucocorticoid | post-translational protein modification | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | spherical high-density lipoprotein particle | cytoplasm | intracellular organelle | lipoprotein particle | endoplasmic reticulum | protein-containing complex | endomembrane system | protein-lipid complex | vesicle | endoplasmic reticulum lumen | extracellular exosome | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | very-low-density lipoprotein particle | high-density lipoprotein particle | extracellular space | membrane-enclosed lumen | early endosome | plasma lipoprotein particle | blood microparticle | cytosol | intracellular vesicle | intracellular | chylomicron
