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QuickView for apoB (gene)


Gene Symbol:
APOB Homo sapiens Homo sapiens
Full name:
apolipoprotein B
Synonyms:
FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B-100, apolipoprotein B (including Ag(x) antigen), apolipoprotein B48
Genomic Location:
Chr 2: 21077806-21120450
Description:
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isof...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2p24.1





GO Molecular Function

low-density lipoprotein particle receptor binding | enzyme binding | lipoprotein particle receptor binding | lipid binding | signaling receptor binding | carbohydrate derivative binding | phospholipid binding | cholesterol transporter activity | anion binding | transporter activity | sterol transporter activity | ion binding | heparin binding | protein binding | lipase binding | glycosaminoglycan binding | lipid transporter activity

GO Biological Process

positive regulation of immune response | response to virus | very-low-density lipoprotein particle assembly | extracellular structure organization | response to cytokine | cell motility | immune response-regulating signaling pathway | response to lipopolysaccharide | regulation of localization | lipid transport | triglyceride catabolic process | establishment of localization | regulation of immune system process | response to hormone | positive regulation of developmental process | cellular response to tumor necrosis factor | male gamete generation | nervous system development | protein-lipid complex assembly | membrane organization | flagellated sperm motility | blood vessel morphogenesis | sterol metabolic process | innate immune response-activating signal transduction | cellular process | toll-like receptor signaling pathway | organic substance catabolic process | localization | protein transport | response to estradiol | triglyceride metabolic process | lipoprotein catabolic process | multicellular organismal reproductive process | macromolecule localization | acylglycerol catabolic process | response to inorganic substance | regulation of cell differentiation | gamete generation | positive regulation of cholesterol storage | response to prostaglandin | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | cellular response to prostaglandin stimulus | catabolic process | organic cyclic compound metabolic process | cellular component organization | cellular lipid metabolic process | response to stimulus | vasculature development | positive regulation of innate immune response | regulation of macrophage derived foam cell differentiation | positive regulation of immune system process | chylomicron assembly | alcohol metabolic process | regulation of plasma lipoprotein particle levels | sterol homeostasis | tube morphogenesis | cholesterol homeostasis | sperm motility | activation of innate immune response | reproduction | lipoprotein biosynthetic process | organic hydroxy compound transport | cardiovascular system development | response to molecule of bacterial origin | lipoprotein transport | cholesterol transporter activity | immune response-activating signal transduction | cellular component assembly | protein modification process | regulation of steroid biosynthetic process | cellular biosynthetic process | embryo development | macromolecule modification | regulation of lipid storage | very-low-density lipoprotein particle clearance | regulation of steroid metabolic process | blood vessel development | leukocyte migration | locomotion | organic hydroxy compound metabolic process | cellular response to hormone stimulus | retinoid metabolic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | reproductive process | pattern recognition receptor signaling pathway | multicellular organism development | cell migration | response to fatty acid | lipid metabolic process | regulation of cholesterol biosynthetic process | artery development | triglyceride mobilization | regulation of gene expression | organic substance transport | response to lipid | protein catabolic process | small molecule metabolic process | peptide transport | vesicle-mediated transport | positive regulation of lipid storage | response to selenium ion | positive regulation of cell differentiation | regulation of cholesterol metabolic process | cellular response to cytokine stimulus | biosynthetic process | sterol transporter activity | sterol transport | plasma lipoprotein particle assembly | fertilization | cholesterol transport | positive regulation of lipid localization | cholesterol efflux | post-embryonic development | plasma lipoprotein particle clearance | response to bacterium | chordate embryonic development | cell communication | cellular lipid catabolic process | positive regulation of macrophage derived foam cell differentiation | lipoprotein metabolic process | homeostatic process | plasma lipoprotein particle remodeling | embryo development ending in birth or egg hatching | glycerolipid metabolic process | regulation of lipid biosynthetic process | cellular response to fatty acid | neutral lipid catabolic process | multicellular organism reproduction | protein-containing complex assembly | activation of immune response | protein metabolic process | response to organic substance | regulation of innate immune response | neutral lipid metabolic process | artery morphogenesis | import into cell | chylomicron remodeling | anatomical structure development | metabolic process | lipid localization | cholesterol metabolic process | chylomicron remnant clearance | amide transport | chemical homeostasis | endocytosis | lipid catabolic process | organic substance metabolic process | diterpenoid metabolic process | establishment of protein localization | organonitrogen compound catabolic process | steroid metabolic process | signaling | response to organic cyclic compound | protein localization | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | response to biotic stimulus | isoprenoid metabolic process | regulation of developmental process | receptor-mediated endocytosis | developmental process | low-density lipoprotein particle remodeling | spermatogenesis | cellular protein modification process | tube development | protein-lipid complex remodeling | in utero embryonic development | regulation of lipid metabolic process | triglyceride-rich lipoprotein particle remodeling | positive regulation of metabolic process | lipid transporter activity | immune system process | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | response to carbohydrate | low-density lipoprotein particle clearance | acylglycerol metabolic process | circulatory system development | sexual reproduction | lipid homeostasis | response to other organism | signal transduction | positive regulation of gene expression | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

mature chylomicron | intracellular membrane-bounded organelle | clathrin-coated endocytic vesicle membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | somatodendritic compartment | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell body | cell | smooth endoplasmic reticulum | neuronal cell body | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | endocytic vesicle lumen | clathrin-coated endocytic vesicle | intracellular organelle | lipoprotein particle | endoplasmic reticulum | endosome membrane | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | intermediate-density lipoprotein particle | plasma membrane | protein-lipid complex | vacuole | vesicle | endoplasmic reticulum lumen | extracellular exosome | lytic vacuole | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | extracellular vesicle | low-density lipoprotein particle | endosome lumen | organelle | very-low-density lipoprotein particle | vesicle membrane | chylomicron remnant | lysosome | extracellular space | cell periphery | membrane-enclosed lumen | early endosome | plasma lipoprotein particle | lysosomal lumen | endoplasmic reticulum exit site | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | vesicle lumen | cytoplasmic vesicle membrane | chylomicron | coated vesicle