QuickView for apoC1 (gene)

Gene Symbol:

APOC1 Homo sapiens

Full name:

apolipoprotein C1

Synonyms:

Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C-I

Genomic Location:

Chr 19: 50109761-50114446

Description:

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit chole...

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This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

LXR_DR4_Q3 ,  LXR_Q3 ,  DR4_Q2

Cytogenetic Map:

19q13.32

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