QuickView for apolipoprotein E (gene)
- Gene Symbol:
- Apoe
Mus musculus - Full name:
- apolipoprotein E
- Synonyms:
- AI255918, Apo-E, apolipoprotein E
- Genomic Location:
- Chr 7: 20281621-20284381
- Description:
-
This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate hi...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
enzyme activator activity | peptide binding | low-density lipoprotein particle receptor binding | amyloid-beta binding | cation binding | phosphatidylcholine-sterol O-acyltransferase activator activity | antioxidant activity | protein-containing complex binding | lipoprotein particle receptor binding | lipid binding | sterol binding | signaling receptor binding | carbohydrate derivative binding | hydroxyapatite binding | phospholipid binding | cholesterol transporter activity | alcohol binding | molecular function regulator | lipoprotein particle binding | cytoskeletal protein binding | anion binding | tau protein binding | amide binding | transporter activity | identical protein binding | sterol transporter activity | ion binding | organic cyclic compound binding | cholesterol binding | heparin binding | protein binding | protein homodimerization activity | protein dimerization activity | glycosaminoglycan binding | enzyme regulator activity | steroid binding | very-low-density lipoprotein particle receptor binding | metal ion binding | lipid transporter activity | metal chelating activity | small molecule binding
GO Biological Process
response to extracellular stimulus | negative regulation of amyloid-beta formation | negative regulation of phosphorylation | regulation of supramolecular fiber organization | long-chain fatty acid transport | regulation of blood vessel diameter | high-density lipoprotein particle clearance | response to nutrient levels | negative regulation of MAPK cascade | extracellular structure organization | long-term memory | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | intracellular signal transduction | regulation of cholesterol transport | enzyme activator activity | regulation of cell development | regulation of localization | regulation of cellular response to very-low-density lipoprotein particle stimulus | lipid transport | regulation of programmed cell death | triglyceride catabolic process | establishment of localization | lipid storage | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | nervous system development | positive regulation of protein catabolic process | AMPA glutamate receptor clustering | negative regulation of protein phosphorylation | cellular chemical homeostasis | protein-lipid complex assembly | positive regulation of axonogenesis | neurogenesis | regulation of protein oligomerization | generation of neurons | membrane organization | positive regulation of heparan sulfate proteoglycan binding | regulation of lipid transport | interaction with symbiont | blood vessel morphogenesis | regulation of neuron death | positive regulation of postsynaptic membrane organization | sterol metabolic process | cellular process | organic substance catabolic process | negative regulation of inflammatory response | monocarboxylic acid transport | regulation of cell motility | localization | cellular homeostasis | phosphatidylcholine-sterol O-acyltransferase activator activity | cellular detoxification | neurotransmitter-gated ion channel clustering | exploration behavior | negative regulation of cholesterol biosynthetic process | protein transport | antioxidant activity | negative regulation of signaling | negative regulation of synapse organization | neuron development | positive regulation of heparan sulfate binding | positive regulation of cholesterol efflux | anion homeostasis | cholesterol catabolic process | triglyceride metabolic process | anion transport | positive regulation of nitric-oxide synthase activity | lipoprotein catabolic process | macromolecule localization | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | positive regulation of oxidoreductase activity | regulation of proteolysis | acylglycerol catabolic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of neuron projection development | regulation of fear response | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of behavior | regulation of binding | negative regulation of presynaptic membrane organization | regulation of cell differentiation | interspecies interaction between organisms | regeneration | regulation of platelet activation | negative regulation of cell motility | negative regulation of wound healing | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | steroid biosynthetic process | cellular component organization | cellular lipid metabolic process | viral life cycle | calcium ion homeostasis | positive regulation of protein binding | positive regulation of cellular protein catabolic process | response to stimulus | vasculature development | regulation of long-term synaptic potentiation | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of blood vessel size | response to stress | negative regulation of protein kinase activity | positive regulation of membrane protein ectodomain proteolysis | alcohol metabolic process | regulation of cell proliferation | positive regulation of lipid biosynthetic process | negative regulation of neuron projection development | regulation of plasma lipoprotein particle levels | sterol homeostasis | tube morphogenesis | cholesterol homeostasis | receptor clustering | positive regulation of receptor catabolic process | lipoprotein biosynthetic process | cellular localization | organic hydroxy compound transport | cardiovascular system development | positive regulation of proteolysis | cellular response to toxic substance | regulation of cholesterol esterification | cholesterol transporter activity | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of wound healing | regulation of axon extension | regulation of synapse structure or activity | modulation of chemical synaptic transmission | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of triglyceride metabolic process | negative regulation of amyloid precursor protein catabolic process | very-low-density lipoprotein particle clearance | regulation of steroid metabolic process | molecular function regulator | metal ion homeostasis | blood vessel development | positive regulation of monooxygenase activity | organic hydroxy compound metabolic process | negative regulation of neuron apoptotic process | positive regulation of low-density lipoprotein particle receptor catabolic process | positive regulation of phospholipid efflux | system development | nitrogen compound metabolic process | alcohol catabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | positive regulation of dendritic spine maintenance | positive regulation of viral process | multicellular organism development | negative regulation of catalytic activity | cGMP-mediated signaling | regulation of MAPK cascade | learning or memory | regulation of axonogenesis | regulation of catalytic activity | steroid catabolic process | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | regulation of cholesterol biosynthetic process | regulation of nitric-oxide synthase activity | localization within membrane | artery development | nitric oxide mediated signal transduction | modulation by host of viral process | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | regulation of gene expression | fatty acid transport | protein localization to membrane | axon development | organic substance transport | cellular response to stress | nervous system process | regulation of behavioral fear response | regulation of postsynaptic membrane organization | protein catabolic process | modification of morphology or physiology of other organism | positive regulation of cellular metabolic process | cellular ion homeostasis | response to axon injury | sterol biosynthetic process | regulation of blood coagulation | regulation of synapse organization | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | positive regulation of cell projection organization | peptide transport | negative regulation of protein serine/threonine kinase activity | vesicle-mediated transport | regulation of cellular component movement | positive regulation by host of viral process | response to oxidative stress | organic acid transport | synapse organization | positive regulation of cell differentiation | regulation of endothelial cell migration | second-messenger-mediated signaling | cognition | regulation of cholesterol metabolic process | positive regulation of cholesterol transport | positive regulation of steroid metabolic process | regulation of Rho protein signal transduction | negative regulation of epithelial cell migration | biosynthetic process | locomotory behavior | sterol transporter activity | sterol transport | plasma lipoprotein particle assembly | neuron projection regeneration | cholesterol biosynthetic process | regulation of cellular protein metabolic process | organic anion transport | triglyceride homeostasis | lipid biosynthetic process | response to toxic substance | cholesterol transport | positive regulation of lipid localization | positive regulation of dendritic spine development | cholesterol efflux | response to caloric restriction | regulation of amyloid precursor protein catabolic process | cation homeostasis | plasma lipoprotein particle clearance | protein import | very-low-density lipoprotein particle remodeling | negative regulation of response to wounding | glutamate receptor clustering | negative regulation of blood vessel endothelial cell migration | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | cellular lipid catabolic process | lipoprotein metabolic process | negative regulation of cell activation | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of cholesterol esterification | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | reverse cholesterol transport | plasma lipoprotein particle remodeling | regulation of locomotion | glycerolipid metabolic process | negative regulation of MAP kinase activity | regulation of tube size | postsynaptic membrane organization | positive regulation of transport | viral process | regulation of lipid biosynthetic process | regulation of viral process | neutral lipid catabolic process | positive regulation of dendrite development | positive regulation of molecular function | positive regulation of axon extension | neuron differentiation | phospholipid transport | protein-containing complex assembly | regulation of protein homooligomerization | regulation of cell morphogenesis involved in differentiation | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of growth | NMDA glutamate receptor clustering | regulation of Cdc42 protein signal transduction | neutral lipid metabolic process | negative regulation of cell projection organization | artery morphogenesis | regulation of kinase activity | response to wounding | import into cell | fatty acid homeostasis | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | phospholipid efflux | anatomical structure development | positive regulation of neurogenesis | vasodilation | negative regulation of lipid metabolic process | cell projection organization | metabolic process | lipid localization | positive regulation of cell development | regulation of protein catabolic process | cellular oxidant detoxification | negative regulation of long-term synaptic potentiation | cholesterol metabolic process | regulation of body fluid levels | negative regulation of programmed cell death | regulation of amyloid fibril formation | chylomicron remnant clearance | regulation of tube diameter | high-density lipoprotein particle remodeling | cellular protein localization | regulation of amyloid-beta clearance | virion assembly | amide transport | regulation of vesicle-mediated transport | negative regulation of endothelial cell proliferation | chemical homeostasis | endocytosis | behavior | neuron projection development | lipid catabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of ion transport | regulation of endothelial cell proliferation | negative regulation of neuron differentiation | negative regulation of cellular protein metabolic process | regulation of cell activation | negative regulation of cellular component movement | regulation of low-density lipoprotein particle receptor catabolic process | ion homeostasis | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of dendritic spine maintenance | positive regulation of binding | establishment of protein localization | regulation of postsynapse organization | memory | negative regulation of protein metabolic process | regulation of dendrite development | regulation of epithelial cell migration | organonitrogen compound catabolic process | steroid metabolic process | regulation of response to wounding | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | regulation of dendritic spine development | signaling | positive regulation of growth | regulation of oxidoreductase activity | regulation of protein binding | regulation of amyloid-beta formation | cell development | regulation of endocytosis | regulation of developmental growth | regulation of presynaptic membrane organization | protein localization | regulation of epithelial cell proliferation | regulation of cell size | enzyme regulator activity | carboxylic acid transport | regulation of Ras protein signal transduction | high-density lipoprotein particle assembly | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of phospholipid transport | axon regeneration | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of cholesterol efflux | receptor-mediated endocytosis | lipid transport involved in lipid storage | developmental process | negative regulation of canonical Wnt signaling pathway | negative regulation of steroid metabolic process | positive regulation of anion transport | low-density lipoprotein particle remodeling | regulation of cell growth | negative regulation of coagulation | acylglycerol homeostasis | tube development | regulation of transport | protein-lipid complex remodeling | negative regulation of cell proliferation | detoxification | response to dietary excess | negative regulation of endothelial cell migration | locomotory exploration behavior | cellular metal ion homeostasis | negative regulation of triglyceride metabolic process | regulation of anion transport | negative regulation of blood coagulation | regulation of lipid metabolic process | triglyceride-rich lipoprotein particle remodeling | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | regulation of synaptic plasticity | positive regulation of neuron differentiation | lipid transporter activity | positive regulation of lipid transport across blood brain barrier | positive regulation of lipid metabolic process | ion transport | regulation of cell projection organization | positive regulation of lipid transport | cellular metabolic process | negative regulation of platelet activation | regulation of cell death | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | acylglycerol metabolic process | negative regulation of cell development | positive regulation of blood vessel diameter | circulatory system development | regulation of inflammatory response | aging | divalent inorganic cation homeostasis | negative regulation of locomotion | positive regulation of endocytosis | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | negative regulation of steroid biosynthetic process | signal transduction | regulation of signaling | amyloid precursor protein metabolic process | macromolecule metabolic process | negative regulation of neurogenesis | maintenance of location in cell | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | dendrite | intracellular membrane-bounded organelle | late endosome | neuron projection | extrinsic component of membrane | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | extrinsic component of plasma membrane | microtubule | external side of plasma membrane | cytoplasm | intracellular organelle | lipoprotein particle | endoplasmic reticulum | dendritic tree | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | intermediate-density lipoprotein particle | plasma membrane | nuclear envelope | protein-lipid complex | vacuole | discoidal high-density lipoprotein particle | vesicle | microtubule cytoskeleton | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | low-density lipoprotein particle | nucleus | organelle | very-low-density lipoprotein particle | lysosome | high-density lipoprotein particle | extracellular space | cell periphery | extrinsic component of external side of plasma membrane | early endosome | plasma lipoprotein particle | intracellular vesicle | cell surface | cytoskeleton | intracellular | membrane | supramolecular complex | chylomicron
