QuickView for atlastin-1 (gene)

Gene Symbol:

ATL1 Homo sapiens

Full name:

atlastin GTPase 1

Synonyms:

AD-FSP, FSP1, GBP3, HSN1D, SPG3, SPG3A, atlastin1, atlastin-1, GBP-3, GTP-binding protein 3, brain-specific GTP-binding protein, guanine nucleotide-binding protein 3, guanylate-binding protein 3, hGBP3, spastic paraplegia 3 protein A

Genomic Location:

Chr 14: 50096500-50169141

Description:

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cau...

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The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  TGANTCA_AP1_C ,  ZIC1_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  CATTGTYY_SOX9_B1 ,  NGFIC_01 ,  CAGTGTT_MIR141_MIR200A ,  EGR2_01 ,  GGGAGGRR_MAZ_Q6 ,  NFE2_01 ,  TGCAAAC_MIR452 ,  GGGYGTGNY_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  RFX1_02 ,  GGGCGGR_SP1_Q6 ,  AHR_Q5 ,  AGGTGCA_MIR500 ,  MEIS1_01 ,  RNGTGGGC_UNKNOWN ,  GTGGGTGK_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-500

Cytogenetic Map:

14q22.1

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