QuickView for bZIP protein (gene)
- Gene Symbol:
- NFE2L1
Homo sapiens - Full name:
- nuclear factor, erythroid 2 like 1
- Synonyms:
- LCR-F1, NRF1, TCF11, nuclear factor erythroid 2-related factor 1, NF-E2-related factor 1, NFE2-related factor 1, TCF-11, locus control region-factor 1, nuclear factor, erythroid derived 2, like 1, transcription factor 11 (basic leucine zipper type), transcription factor HBZ17, transcription factor LCR-F1
- Genomic Location:
- Chr 17: 43480745-43493841
- Description:
-
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-145 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-199 , Predicted Gene Targets for miR-218 , Predicted Gene Targets for miR-330 , Predicted Gene Targets for miR-338 , Predicted Gene Targets for miR-34 , Predicted Gene Targets for miR-503 , Predicted Gene Targets for miR-505
- Cytogenetic Map:
-
17q21.32
| Transcripts Names |
|---|
| NM_003204 |
| NM_001330262 |
| XM_005257411 |
| NM_001330261 |
| XM_005257412 |
| XM_005257415 |
| XM_005257410 |
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | transcription factor activity, RNA polymerase II transcription factor binding | nucleic acid binding | protein-containing complex binding | lipid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | protein domain specific binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | erythrocyte homeostasis | myeloid cell differentiation | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cell differentiation | defense response | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | immune system development | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | heme metabolic process | porphyrin-containing compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | response to stress | cellular nitrogen compound biosynthetic process | alcohol metabolic process | tetrapyrrole biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cofactor metabolic process | hemopoiesis | cellular biosynthetic process | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | organic hydroxy compound metabolic process | system development | nitrogen compound metabolic process | multicellular organism development | lipid metabolic process | cellular response to oxidative stress | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | cofactor biosynthetic process | pigment biosynthetic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | regulation of transcription by RNA polymerase II | response to oxidative stress | heme biosynthetic process | homeostasis of number of cells | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | inflammatory response | homeostatic process | regulation of RNA metabolic process | transcriptional activator activity, RNA polymerase II transcription factor binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | cholesterol metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | pigment metabolic process | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | steroid metabolic process | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | erythrocyte differentiation | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | porphyrin-containing compound biosynthetic process | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular | membrane
