QuickView for cathepsin K (gene)

Gene Symbol:

CTSK Homo sapiens

Full name:

cathepsin K

Synonyms:

CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K, cathepsin O, cathepsin O1, cathepsin O2, cathepsin X

Genomic Location:

Chr 1: 149035311-149047436

Description:

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to ...

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The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  POU6F1_01 ,  STAT4_01 ,  RYTTCCTG_ETS2_B ,  AML_Q6 ,  YTATTTTNR_MEF2_02 ,  IPF1_Q4 ,  SRY_01 ,  ZIC3_01 ,  AML1_01 ,  CEBP_Q2 ,  RREB1_01 ,  NKX25_02 ,  MEIS1_01 ,  OCT1_06 ,  AML1_Q6 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  TGACAGNY_MEIS1_01 ,  TCF11_01

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Cytogenetic Map:

1q21.3

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