QuickView for cdc25c (gene)
- Gene Symbol:
- CDC25C
Homo sapiens - Full name:
- cell division cycle 25C
- Synonyms:
- CDC25, PPP1R60, M-phase inducer phosphatase 3, dual specificity phosphatase CDC25C, mitosis inducer CDC25, phosphotyrosine phosphatase, protein phosphatase 1, regulatory subunit 60
- Genomic Location:
- Chr 5: 137648858-137695415
- Description:
-
This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q31.2
GO Molecular Function
kinase binding | WW domain binding | protein kinase binding | enzyme binding | phosphatase activity | hydrolase activity | protein tyrosine phosphatase activity | catalytic activity | protein domain specific binding | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | protein binding | phosphoric ester hydrolase activity
GO Biological Process
regulation of cell cycle process | protein dephosphorylation | intracellular signal transduction | regulation of cell cycle G1/S phase transition | regulation of meiotic cell cycle | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | male gamete generation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of organelle organization | positive regulation of meiotic cell cycle phase transition | cellular process | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | regulation of mitotic nuclear division | multicellular organismal reproductive process | regulation of cell cycle | gamete generation | interspecies interaction between organisms | regulation of cellular process | regulation of metabolic process | positive regulation of cell cycle phase transition | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | phosphatase activity | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | regulation of cell cycle phase transition | reproduction | positive regulation of meiotic cell cycle | protein modification process | macromolecule modification | protein tyrosine phosphatase activity | regulation of cell cycle G2/M phase transition | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | cellular response to stress | cell cycle | regulation of cell cycle arrest | phosphoprotein phosphatase activity | regulation of nitrogen compound metabolic process | positive regulation of cell cycle G2/M phase transition | cell proliferation | positive regulation of G2/MI transition of meiotic cell cycle | cell division | regulation of cellular protein metabolic process | G2/M transition of mitotic cell cycle | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | phosphate-containing compound metabolic process | regulation of meiotic cell cycle phase transition | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | cell cycle G2/M phase transition | regulation of protein phosphorylation | viral process | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | multicellular organism reproduction | protein metabolic process | G1 DNA damage checkpoint | regulation of kinase activity | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | metabolic process | negative regulation of mitotic cell cycle | organic substance metabolic process | signal transduction involved in mitotic cell cycle checkpoint | regulation of phosphate metabolic process | negative regulation of cell cycle | negative regulation of cell cycle G1/S phase transition | dephosphorylation | signaling | cellular protein metabolic process | signal transduction involved in DNA damage checkpoint | positive regulation of cell cycle process | spermatogenesis | cellular protein modification process | mitotic G1/S transition checkpoint | peptidyl-tyrosine dephosphorylation | cell cycle phase transition | signal transduction involved in mitotic G1 DNA damage checkpoint | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | sexual reproduction | regulation of cellular component organization | signal transduction | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | nucleoplasm | nuclear speck | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
