QuickView for ced5 (gene)

Gene Symbol:

DOCK1 Homo sapiens

Full name:

dedicator of cytokinesis 1

Synonyms:

DOCK180, ced5, dedicator of cytokinesis protein 1, 180 kDa protein downstream of CRK, DOwnstream of CrK

Genomic Location:

Chr 10: 128658955-129140770

Description:

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of th...

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This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HFH1_01 ,  IPF1_Q4 ,  MYB_Q5_01 ,  CTTTGTA_MIR524 ,  GTGCCAA_MIR96 ,  MYB_Q6 ,  ATAACCT_MIR154

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

10q26.2

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