QuickView for class I antigens (compound)

Name:	Histocompatibility Antigens Class I
Description:	Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Synonyms:	Class I Major Histocompatibility Antigens; Class I Histocompatibility Antigens; Class I Antigens; Antigens, Class I; I Antigens, Class