Name: | Collagenases |
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Name (isomeric): | DB00048 |
Drug Type: | biotech |
Description: | Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. EC 3.4.24.-. |
Synonyms: |
AA4500
|
Brand: | Xiaflextm, Santyl (Advance Biofactures Corp), Cordase |
Category: | Topical, Anti-Ulcer Agents |
CAS number: | 9001-12-1 |
Indication: | Used to promote debridement of necrotic tissue in the treatment of severe burns and dermal ulcers including decubitus ulcers. |
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Pharmacology: |
Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH by hydrolyzing the peptide bonds of undenatured and denatured collagen. Collagenase thus contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas....
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Mechanism of Action: |
Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Collagenase cleaves all 3 alpha hel...
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Affected organisms: | Humans and other mammals |