QuickView for cyclin Cdc13 (gene)
- Gene Symbol:
- CCNB1
Homo sapiens - Full name:
- cyclin B1
- Synonyms:
- CCNB, G2/mitotic-specific cyclin-B1
- Genomic Location:
- Chr 5: 68498669-68509828
- Description:
-
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Pan troglodytes , Danio rerio , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q13.2
GO Molecular Function
protein kinase activator activity | protein serine/threonine kinase activator activity | kinase binding | enzyme activator activity | protein kinase regulator activity | patched binding | kinase regulator activity | cyclin-dependent protein serine/threonine kinase activator activity | protein kinase binding | enzyme binding | cyclin-dependent protein kinase activity | signaling receptor binding | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | ubiquitin-like protein ligase binding | protein binding | histone kinase activity | cyclin-dependent protein serine/threonine kinase activity | kinase activator activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | enzyme regulator activity | kinase activity | cyclin-dependent protein serine/threonine kinase regulator activity
GO Biological Process
positive regulation of cyclin-dependent protein serine/threonine kinase activity | negative regulation of phosphorylation | nucleus organization | regulation of cell cycle process | protein kinase activator activity | cellular response to decreased oxygen levels | protein serine/threonine kinase activator activity | microtubule cytoskeleton organization involved in mitosis | positive regulation of cellular component organization | developmental process involved in reproduction | muscle tissue development | positive regulation of ATP metabolic process | intracellular signal transduction | enzyme activator activity | proteolysis | regulation of cell cycle G1/S phase transition | protein kinase regulator activity | positive regulation of striated muscle tissue development | peptidyl-amino acid modification | establishment of localization | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | positive regulation of developmental process | response to metal ion | histone modification | microtubule cytoskeleton organization | regulation of heart growth | cell differentiation | positive regulation of fibroblast proliferation | male gamete generation | striated muscle cell development | response to drug | negative regulation of protein phosphorylation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | cellular response to iron ion | positive regulation of phosphate metabolic process | regulation of organelle organization | cardiac cell development | membrane organization | microtubule-based process | regulation of mRNA processing | regulation of cardiac muscle cell proliferation | positive regulation of oxidative phosphorylation | regulation of attachment of spindle microtubules to kinetochore | regulation of chromosome segregation | histone H3-S10 phosphorylation involved in chromosome condensation | cellular process | organic substance catabolic process | establishment of organelle localization | localization | proteolysis involved in cellular protein catabolic process | chromatin organization | cell maturation | mitotic DNA integrity checkpoint | developmental growth | negative regulation of G1/S transition of mitotic cell cycle | kinase regulator activity | cyclin-dependent protein serine/threonine kinase activator activity | regulation of mitotic nuclear division | multicellular organismal reproductive process | regulation of chromosome separation | regulation of striated muscle tissue development | positive regulation of protein kinase activity | regulation of histone modification | endomembrane system organization | response to hypoxia | regulation of cell cycle | positive regulation of catalytic activity | membrane disassembly | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | gamete generation | regulation of oxidative phosphorylation | muscle structure development | muscle cell differentiation | regeneration | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | organelle localization | positive regulation of cyclin-dependent protein kinase activity | positive regulation of cell cycle phase transition | ventricular cardiac muscle cell development | regulation of mitotic cell cycle spindle assembly checkpoint | positive regulation of cellular protein metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | cellular component organization | establishment of chromosome localization | cellular response to metal ion | response to stimulus | regulation of mitochondrial ATP synthesis coupled electron transport | cyclin-dependent protein kinase activity | muscle cell development | female gamete generation | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | mitotic spindle organization | cellular response to hypoxia | response to stress | germ cell development | regulation of cell proliferation | anaphase-promoting complex-dependent catabolic process | cardiac muscle tissue development | regulation of cell cycle phase transition | mitotic nuclear envelope disassembly | protein serine/threonine kinase activity | reproduction | cellular response to inorganic substance | cellular protein catabolic process | cellular localization | proteasomal protein catabolic process | nuclear envelope organization | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | cellular component assembly | positive regulation of mRNA processing | protein modification process | embryo development | response to iron ion | macromolecule modification | activation of protein kinase activity | molecular function regulator | regulation of chromosome condensation | regulation of cell cycle G2/M phase transition | regulation of histone phosphorylation | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | negative regulation of phosphate metabolic process | mitotic DNA damage checkpoint | multicellular organism development | sister chromatid segregation | phosphorus metabolic process | response to fatty acid | histone H3-S10 phosphorylation | cellular response to DNA damage stimulus | positive regulation of muscle organ development | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | oocyte differentiation | regulation of phosphorylation | wound healing | positive regulation of chromosome organization | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | response to lipid | cell cycle | protein catabolic process | chromosome condensation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | mitotic metaphase plate congression | regulation of mRNA 3'-end processing | cellular response to oxygen levels | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | positive regulation of attachment of spindle microtubules to kinetochore | cardiocyte differentiation | oogenesis | positive regulation of cell cycle G2/M phase transition | positive regulation of cellular respiration | positive regulation of cardiac muscle cell proliferation | cell division | metaphase plate congression | regulation of cellular protein metabolic process | cardiac muscle cell development | G2/M transition of mitotic cell cycle | phosphorylation | digestive tract development | response to toxic substance | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | nuclear chromosome segregation | mitotic G1 DNA damage checkpoint | chordate embryonic development | striated muscle tissue development | nuclear envelope disassembly | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | heart development | cell cycle G2/M phase transition | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | histone phosphorylation | striated muscle cell differentiation | cellular response to fatty acid | proteasome-mediated ubiquitin-dependent protein catabolic process | response to insecticide | regulation of mitotic cell cycle | positive regulation of molecular function | positive regulation of cell cycle arrest | multicellular organism reproduction | protein-containing complex assembly | positive regulation of organ growth | protein metabolic process | regulation of fibroblast proliferation | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of cardiac muscle tissue development | G1 DNA damage checkpoint | digestive system development | histone kinase activity | regulation of cellular respiration | regulation of kinase activity | response to wounding | response to mechanical stimulus | cyclin-dependent protein serine/threonine kinase activity | cellular macromolecule catabolic process | regulation of sister chromatid segregation | anatomical structure development | kinase activator activity | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | nuclear division | metabolic process | developmental maturation | negative regulation of mitotic cell cycle | histone-serine phosphorylation | protein kinase activity | organic substance metabolic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | positive regulation of chromosome segregation | signal transduction involved in mitotic cell cycle checkpoint | positive regulation of kinase activity | cellular response to iron(III) ion | positive regulation of mRNA 3'-end processing | regulation of ATP metabolic process | regulation of phosphate metabolic process | DNA packaging | cytoskeleton organization | regulation of chromosome organization | mitotic nuclear division | positive regulation of muscle tissue development | response to iron(III) ion | oocyte development | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | negative regulation of protein metabolic process | organonitrogen compound catabolic process | cardiac muscle cell differentiation | regulation of mitotic sister chromatid segregation | negative regulation of cell cycle G1/S phase transition | positive regulation of developmental growth | signaling | covalent chromatin modification | positive regulation of growth | response to organic cyclic compound | cell development | regulation of developmental growth | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of organ growth | signal transduction involved in DNA damage checkpoint | regulation of developmental process | response to DDT | kinase activity | developmental process | organelle organization | positive regulation of cell cycle process | peptidyl-serine phosphorylation | spermatogenesis | cellular protein modification process | mitotic G1/S transition checkpoint | tube development | regulation of mitotic metaphase/anaphase transition | positive regulation of heart growth | DNA conformation change | cell cycle phase transition | ventricular cardiac muscle cell differentiation | oocyte maturation | signal transduction involved in mitotic G1 DNA damage checkpoint | regulation of generation of precursor metabolites and energy | in utero embryonic development | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | positive regulation of cardiac muscle tissue development | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | positive regulation of histone phosphorylation | circulatory system development | spindle organization | mitotic sister chromatid segregation | tissue regeneration | sexual reproduction | regulation of cellular component organization | signal transduction | positive regulation of gene expression | cyclin-dependent protein serine/threonine kinase regulator activity | regulation of muscle organ development | macromolecule metabolic process | positive regulation of mitochondrial ATP synthesis coupled electron transport | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
condensed nuclear chromosome | cyclin B1-CDK1 complex | mitochondrial matrix | chromosome | intracellular membrane-bounded organelle | catalytic complex | condensed nuclear chromosome kinetochore | microtubule organizing center | chromosome, centromeric region | condensed chromosome outer kinetochore | condensed chromosome, centromeric region | protein kinase complex | cell | nuclear lumen | kinetochore | cytoplasm | spindle | intracellular organelle | centrosome | protein-containing complex | nucleoplasm | condensed nuclear chromosome, centromeric region | nuclear chromosome | transferase complex | condensed chromosome kinetochore | microtubule cytoskeleton | mitochondrion | spindle pole | serine/threonine protein kinase complex | membrane-bounded organelle | condensed nuclear chromosome outer kinetochore | nucleus | organelle | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | cytosol | cytoskeleton | intracellular | membrane | condensed chromosome
