QuickView for decorin (gene)

Gene Symbol:

Dcn Mus musculus

Full name:

decorin

Synonyms:

DC, DSPG2, PG40, PGII, PGS2, SLRR1B, decorin, bone proteoglycan II

Genomic Location:

Chr 10: 96945001-96980785

Description:

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a live...

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This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  MZF1_01 ,  CEBPB_01 ,  OCT1_02 ,  OCT1_03 ,  OCT1_05 ,  AP1FJ_Q2 ,  AP1_Q2 ,  AP1_Q6 ,  CEBP_C ,  GATA_C ,  FREAC3_01 ,  IPF1_Q4 ,  POU3F2_02 ,  HNF4ALPHA_Q6 ,  CACBINDINGPROTEIN_Q6 ,  CEBP_Q2_01 ,  AP1_Q6_01 ,  GTGGGTGK_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  YAATNANRNNNCAG_UNKNOWN ,  TAATTA_CHX10_01 ,  CAGGTG_E12_Q6 ,  TTGTTT_FOXO4_01 ,  RTAAACA_FREAC2_01 ,  CTTTGA_LEF1_Q2 ,  TGGAAA_NFAT_Q4_01 ,  YATGNWAAT_OCT_C ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-496

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