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QuickView for diamine oxidase (gene)


Gene Symbol:
AOC1 Homo sapiens Homo sapiens
Full name:
amine oxidase, copper containing 1
Synonyms:
ABP, ABP1, DAO, DAO1, KAO, amiloride-sensitive amine oxidase [copper-containing], amiloride binding protein 1 (amine oxidase (copper-containing)), amiloride-binding protein 1, amiloride-sensitive amine oxidase, amine oxidase copper domain-containing protein 1, diamine oxidase, histaminase, kidney amine oxidase
Genomic Location:
Chr 7: 150180506-150189312
Description:
This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q36.1





GO Molecular Function

methylputrescine oxidase activity | cofactor binding | cation binding | diamine oxidase activity | protein-containing complex binding | carbohydrate derivative binding | catalytic activity | anion binding | identical protein binding | ion binding | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | heparin binding | copper ion binding | primary amine oxidase activity | protein binding | protein homodimerization activity | zinc ion binding | histamine oxidase activity | protein dimerization activity | oxidoreductase activity, acting on the CH-NH2 group of donors | glycosaminoglycan binding | transition metal ion binding | calcium ion binding | propane-1,3-diamine oxidase activity | quinone binding | drug binding | metal ion binding | oxidoreductase activity

GO Biological Process

response to extracellular stimulus | response to nutrient levels | exocytosis | neutrophil activation | methylputrescine oxidase activity | establishment of localization | response to metal ion | cellular response to extracellular stimulus | response to drug | cellular response to azide | response to antibiotic | cellular process | secretion | leukocyte degranulation | localization | cellular response to starvation | response to inorganic substance | diamine oxidase activity | leukocyte activation | xenobiotic metabolic process | cellular response to organonitrogen compound | cellular response to metal ion | response to stimulus | neutrophil degranulation | cellular response to xenobiotic stimulus | response to stress | leukocyte activation involved in immune response | response to starvation | cellular response to inorganic substance | secretion by cell | cellular response to organic cyclic compound | amine metabolic process | response to nitrogen compound | cellular response to nutrient levels | nitrogen compound metabolic process | leukocyte mediated immunity | cellular response to ammonium ion | cellular response to stress | response to ammonium ion | vesicle-mediated transport | regulated exocytosis | response to xenobiotic stimulus | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | cellular response to drug | cell communication | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | primary amine oxidase activity | response to histamine | histamine oxidase activity | response to organic substance | cellular response to heparin | metabolic process | oxidation-reduction process | immune response | organic substance metabolic process | response to copper ion | oxidoreductase activity, acting on the CH-NH2 group of donors | response to anticoagulant | cell activation | response to organic cyclic compound | propane-1,3-diamine oxidase activity | response to azide | neutrophil mediated immunity | response to organonitrogen compound | cellular response to histamine | immune system process | cellular metabolic process | cellular response to organic substance | cellular response to copper ion | oxidoreductase activity | cellular response to copper ion starvation | response to heparin

GO Cellular Component

secretory granule | occluding junction | intracellular membrane-bounded organelle | peroxisome | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | cell-cell junction | secretory vesicle | endomembrane system | plasma membrane | vesicle | extracellular exosome | specific granule | extracellular region | membrane-bounded organelle | extracellular vesicle | specific granule lumen | apical junction complex | organelle | extracellular space | cell periphery | bicellular tight junction | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | cell junction | membrane | vesicle lumen