QuickView for dystroglycan (gene)

Gene Symbol:

DAG1 Homo sapiens

Full name:

dystroglycan 1

Synonyms:

156DAG, A3a, AGRNR, DAG, MDDGA9, MDDGC7, MDDGC9, dystroglycan, dystroglycan 1 (dystrophin-associated glycoprotein 1)

Genomic Location:

Chr 3: 49482569-49548052

Description:

This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct...

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This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  GAGCCTG_MIR484 ,  AAGCCAT_MIR135A_MIR135B ,  CCCAGAG_MIR326 ,  AAAGGGA_MIR204_MIR211 ,  TTTTGAG_MIR373 ,  CTTTGCA_MIR527 ,  AACTGGA_MIR145 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTACTGT_MIR101 ,  AGGAGTG_MIR483 ,  GGTGAAG_MIR412 ,  TCTGATA_MIR361 ,  CTCAGGG_MIR125B_MIR125A ,  CAGCTTT_MIR320 ,  GTTTGTT_MIR495 ,  GACTGTT_MIR212_MIR132 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CCAGGGG_MIR331 ,  TGCTTTG_MIR330 ,  AGGGCAG_MIR18A ,  CAGCCTC_MIR4855P ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  GGCAGTG_MIR3243P ,  ACCATTT_MIR522 ,  ACATATC_MIR190

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

3p21.31

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