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QuickView for eEF2 (gene)


Gene Symbol:
EEF2 Homo sapiens Homo sapiens
Full name:
eukaryotic translation elongation factor 2
Synonyms:
EEF-2, EF-2, EF2, SCA26, elongation factor 2, polypeptidyl-tRNA translocase
Genomic Location:
Chr 19: 3927054-3936461
Description:
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.3


Transcripts Names
NM_001961
Protein Names
D6W618
P13639
B2RMP5
Q58J86



GO Molecular Function

actin binding | kinase binding | guanyl ribonucleotide binding | actin filament binding | ribonucleoside binding | translation elongation factor activity | cadherin binding | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | hydrolase activity | 5S rRNA binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | ribonucleoprotein complex binding | cytoskeletal protein binding | anion binding | nucleoside-triphosphatase activity | p53 binding | purine nucleotide binding | translation factor activity, RNA binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | ribosome binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | rRNA binding | guanyl nucleotide binding | small molecule binding | RNA binding

GO Biological Process

response to extracellular stimulus | multicellular organismal movement | glial cell proliferation | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to endoplasmic reticulum stress | exocytosis | neutrophil activation | muscle tissue development | establishment of localization | response to hormone | cell differentiation | translational elongation | nervous system development | response to drug | neurogenesis | response to antibiotic | translation elongation factor activity | response to folic acid | positive regulation of cellular biosynthetic process | cellular process | secretion | musculoskeletal movement | leukocyte degranulation | localization | response to estradiol | immune system development | response to growth factor | positive regulation of nitrogen compound metabolic process | response to inorganic substance | tissue development | muscle structure development | skeletal muscle organ development | response to hydrogen peroxide | regulation of cellular process | leukocyte activation | regulation of metabolic process | gliogenesis | response to nerve growth factor | positive regulation of translation | positive regulation of cellular protein metabolic process | muscle contraction | response to stimulus | peptide biosynthetic process | neutrophil degranulation | positive regulation of protein metabolic process | response to stress | leukocyte activation involved in immune response | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | hematopoietic progenitor cell differentiation | secretion by cell | response to alcohol | cellular nitrogen compound metabolic process | response to ischemia | hemopoiesis | cellular biosynthetic process | response to ethanol | response to nitrogen compound | system development | nitrogen compound metabolic process | multicellular organism development | leukocyte mediated immunity | cellular response to nerve growth factor stimulus | regulation of gene expression | cellular response to stress | response to lipid | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | cellular amide metabolic process | vesicle-mediated transport | response to nutrient | response to oxidative stress | translation | translation factor activity, RNA binding | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | regulated exocytosis | response to toxic substance | striated muscle tissue development | regulation of cellular metabolic process | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | neutrophil activation involved in immune response | peptide metabolic process | striated muscle contraction | protein metabolic process | response to organic substance | anatomical structure development | metabolic process | immune response | organic substance metabolic process | response to vitamin | animal organ development | response to reactive oxygen species | gene expression | amide biosynthetic process | cellular response to brain-derived neurotrophic factor stimulus | positive regulation of cytoplasmic translation | regulation of cytoplasmic translation | cell activation | response to organic cyclic compound | skeletal muscle contraction | cellular protein metabolic process | cellular macromolecule biosynthetic process | developmental process | neutrophil mediated immunity | response to organonitrogen compound | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of translation | aging | skeletal muscle cell differentiation | muscle organ development | muscle system process | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | polysomal ribosome | polysome | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ribosome | membrane microdomain | ficolin-1-rich granule lumen | inclusion body | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | membrane raft | ribonucleoprotein complex | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | aggresome | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | secretory granule lumen | cytosol | intracellular vesicle | intracellular | membrane | vesicle lumen