QuickView for eIF4G1 (gene)

Gene Symbol:

EIF4G1 Homo sapiens

Full name:

eukaryotic translation initiation factor 4 gamma 1

Synonyms:

EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, eukaryotic translation initiation factor 4 gamma 1, EIF4-gamma, eIF-4-gamma 1, eucaryotic translation initiation factor 4G

Genomic Location:

Chr 3: 185515050-185535840

Description:

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed ...

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The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  HNF4ALPHA_Q6 ,  MAZR_01 ,  TGANTCA_AP1_C ,  USF_Q6 ,  STAT1_02 ,  TCANNTGAY_SREBP1_01 ,  MZF1_01 ,  ZIC1_01 ,  AP3_Q6 ,  FOXO4_01 ,  SYATTGTG_UNKNOWN ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  AAAYWAACM_HFH4_01 ,  ATF4_Q2 ,  AREB6_04 ,  ARNT_02 ,  CGCTGCT_MIR503 ,  CTTTGA_LEF1_Q2 ,  STAT1_03 ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  GGTGTGT_MIR329 ,  NFE2_01 ,  STAT3_02 ,  AP1_Q6_01 ,  SREBP1_01 ,  CAGGTA_AREB6_01 ,  RREB1_01 ,  DR1_Q3 ,  AP1FJ_Q2 ,  SP3_Q3 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  AP1_Q2_01 ,  E2F1_Q3_01 ,  ACTGCAG_MIR173P ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  HFH4_01 ,  USF_01 ,  NRF2_Q4 ,  AP1_Q4 ,  PTF1BETA_Q6 ,  GATA2_01 ,  HMGIY_Q6 ,  NMYC_01 ,  BACH1_01 ,  HAND1E47_01 ,  ELK1_01 ,  USF_Q6_01 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  YY1_02 ,  HEN1_02 ,  CREL_01 ,  AP1_Q2 ,  CTTTGT_LEF1_Q2 ,  CACBINDINGPROTEIN_Q6 ,  ELK1_02 ,  AACTTT_UNKNOWN ,  GGCAGTG_MIR3243P ,  PPAR_DR1_Q2 ,  DR4_Q2 ,  PAX2_02 ,  HIF1_Q3 ,  HNF4_01_B ,  RACTNNRTTTNC_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  TCF11MAFG_01 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-503

Cytogenetic Map:

3q27.1

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