QuickView for elastin (gene)

Gene Symbol:

Eln Mus musculus

Full name:

elastin

Synonyms:

AI385707, AI480567, E030024M20Rik, elastin, tropoelastin

Genomic Location:

Chr 5: 135178466-135223124

Description:

This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exh...

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This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CCANNAGRKGGC_UNKNOWN ,  EN1_01 ,  PU1_Q6 ,  HEB_Q6 ,  SMAD_Q6 ,  CAGCTG_AP4_Q5 ,  CAGGTG_E12_Q6 ,  GGGTGGRR_PAX4_03 ,  RGAGGAARY_PU1_Q6 ,  GGGCGGR_SP1_Q6

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