QuickView for emilin-1 (gene)
- Gene Symbol:
- EMILIN1
Homo sapiens - Full name:
- elastin microfibril interfacer 1
- Synonyms:
- EMI, EMILIN, gp115, EMILIN-1, elastin microfibril interface-located protein 1
- Genomic Location:
- Chr 2: 27155438-27162767
- Description:
-
This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the d...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TFIIA_Q6 , PR_01 , GR_Q6_01 , CTCNANGTGNY_UNKNOWN , GGGAGGRR_MAZ_Q6 , CDPCR3HD_01 , LFA1_Q6 , TGCCAAR_NF1_Q6 , GR_01 , CDC5_01
- Cytogenetic Map:
-
2p23.3
GO Molecular Function
structural molecule activity | protein-containing complex binding | signaling receptor binding | integrin binding involved in cell-matrix adhesion | identical protein binding | integrin binding | cell adhesion molecule binding | protein binding | structural molecule activity conferring elasticity | extracellular matrix constituent conferring elasticity | cell adhesion mediator activity | extracellular matrix structural constituent
GO Biological Process
regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | regulation of supramolecular fiber organization | protein homooligomerization | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | negative regulation of immune system process | extracellular structure organization | positive regulation of cellular component organization | cell motility | regulation of localization | cell-substrate adhesion | regulation of immune system process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | negative regulation of RNA biosynthetic process | regulation of extracellular matrix organization | negative regulation of protein phosphorylation | positive regulation of cell adhesion | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | negative regulation of signaling | regulation of vascular endothelial growth factor receptor signaling pathway | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of macrophage migration | negative regulation of cellular metabolic process | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | positive regulation of extracellular matrix organization | cellular component organization | regulation of vasculature development | negative regulation of vascular endothelial growth factor receptor signaling pathway | negative regulation of extracellular matrix organization | negative regulation of angiogenesis | protein homotrimerization | extracellular matrix organization | positive regulation of extracellular matrix assembly | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of cell adhesion | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | negative regulation of ERK1 and ERK2 cascade | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | locomotion | system development | regulation of signal transduction | negative regulation of phosphate metabolic process | integrin binding involved in cell-matrix adhesion | multicellular organism development | cell migration | regulation of MAPK cascade | protein complex oligomerization | regulation of phosphorylation | elastic fiber assembly | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | negative regulation of cellular response to growth factor stimulus | regulation of cellular component movement | aortic valve morphogenesis | regulation of cellular protein metabolic process | regulation of leukocyte migration | regulation of cellular metabolic process | protein trimerization | semi-lunar valve development | negative regulation of cell activation | regulation of protein metabolic process | heart development | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | protein-containing complex assembly | heart valve development | negative regulation of transforming growth factor beta receptor signaling pathway | negative regulation of pathway-restricted SMAD protein phosphorylation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cell adhesion | positive regulation of cellular component biogenesis | heart valve morphogenesis | regulation of extracellular matrix assembly | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of cell-substrate adhesion | negative regulation of cellular protein metabolic process | regulation of cell activation | negative regulation of cellular component movement | regulation of phosphate metabolic process | negative regulation of protein metabolic process | regulation of cell communication | cell adhesion mediator activity | negative regulation of signal transduction | regulation of transcription, DNA-templated | cell-matrix adhesion | anatomical structure morphogenesis | extracellular matrix assembly | negative regulation of leukocyte migration | regulation of developmental process | developmental process | positive regulation of transcription, DNA-templated | aortic valve development | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | negative regulation of supramolecular fiber organization | positive regulation of metabolic process | circulatory system development | negative regulation of locomotion | regulation of cellular component organization | negative regulation of collagen fibril organization | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | extracellular matrix | cell | plasma membrane protein complex | intrinsic component of membrane | integrin complex | collagen-containing extracellular matrix | receptor complex | integrin alpha4-beta1 complex | protein-containing complex | plasma membrane | vesicle | collagen trimer | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | protein complex involved in cell adhesion | membrane | EMILIN complex | intrinsic component of plasma membrane
