QuickView for endothelin 1 (gene)

GO Molecular Function

endothelin A receptor binding | signaling receptor binding | bombesin receptor binding | hormone activity | neuropeptide receptor binding | molecular function regulator | endothelin B receptor binding | protein binding | receptor regulator activity | G-protein coupled receptor binding | receptor ligand activity | cytokine activity

GO Biological Process

regulation of JUN kinase activity | positive regulation of smooth muscle cell proliferation | positive regulation of heart contraction | regulation of leukocyte chemotaxis | negative regulation of smooth muscle cell apoptotic process | positive regulation of striated muscle cell differentiation | regulation of supramolecular fiber organization | respiratory gaseous exchange | positive regulation of sarcomere organization | regulation of blood vessel diameter | regulation of muscle system process | regulation of cell cycle process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | positive regulation of blood circulation | regulation of systemic arterial blood pressure by hormone | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | cell motility | response to lipopolysaccharide | intracellular signal transduction | regulation of cell development | regulation of localization | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | positive regulation of striated muscle tissue development | phospholipase D-activating G-protein coupled receptor signaling pathway | regulation of programmed cell death | vascular smooth muscle contraction | hormone secretion | regulation of cardiac muscle cell differentiation | superoxide metabolic process | establishment of localization | regulation of immune system process | response to hormone | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | response to dexamethasone | negative regulation of RNA biosynthetic process | response to metal ion | cellular response to tumor necrosis factor | regulation of heart growth | negative regulation of nitric-oxide synthase biosynthetic process | cell differentiation | defense response | fluid transport | regulation of smooth muscle contraction | response to drug | reactive oxygen species metabolic process | cellular chemical homeostasis | inositol phosphate-mediated signaling | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | tonic smooth muscle contraction | regulation of renal sodium excretion | response to antibiotic | mesenchyme development | regulation of lipid transport | blood vessel morphogenesis | pattern specification process | positive regulation of vascular smooth muscle cell proliferation | histamine secretion | artery smooth muscle contraction | positive regulation of cellular biosynthetic process | cellular process | unsaturated fatty acid biosynthetic process | secretion | peptide hormone secretion | regulation of cell motility | localization | cellular homeostasis | epithelial tube morphogenesis | negative regulation of signaling | regulation of cell growth involved in cardiac muscle cell development | positive regulation of reactive oxygen species metabolic process | regulation of mitotic nuclear division | azole transport | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | regulation of chemotaxis | negative regulation of apoptotic process | negative regulation of secretion | response to hypoxia | positive regulation of oxidoreductase activity | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | negative regulation of hormone secretion | transepithelial transport | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of neurological system process | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | histamine transport | positive regulation of muscle cell differentiation | response to prostaglandin | negative regulation of wound healing | regulation of cellular process | leukocyte activation | positive regulation of cell growth | parturition | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of neutrophil migration | positive regulation of stress-activated MAPK cascade | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | epithelium development | positive regulation of renal sodium excretion | cellular response to organonitrogen compound | icosanoid biosynthetic process | smooth muscle contraction | regulation of urine volume | cellular component organization | superoxide anion generation | cellular lipid metabolic process | regulation of systemic arterial blood pressure mediated by a chemical signal | calcium ion homeostasis | regulation of neutrophil chemotaxis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | response to transforming growth factor beta | cellular response to metal ion | positive regulation of epithelial cell migration | cellular response to interferon-gamma | positive regulation of stress-activated protein kinase signaling cascade | muscle contraction | branching involved in blood vessel morphogenesis | response to stimulus | vasculature development | positive regulation of NIK/NF-kappaB signaling | regulation of sarcomere organization | mesenchymal cell development | monocarboxylic acid metabolic process | neutrophil chemotaxis | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | regulation of excretion | positive regulation of protein metabolic process | regulation of blood vessel size | cellular response to hypoxia | response to stress | response to ozone | regulation of cell proliferation | tube morphogenesis | regulation of blood circulation | response to peptide | response to muscle stretch | phosphatidylinositol-mediated signaling | regulation of heart rate | reproduction | cellular response to inorganic substance | secretion by cell | cardiovascular system development | response to molecule of bacterial origin | positive regulation of hormone secretion | negative regulation of transport | cellular response to organic cyclic compound | hormone activity | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of wound healing | regulation of odontogenesis | cartilage development | modulation of chemical synaptic transmission | cellular biosynthetic process | dorsal/ventral pattern formation | embryo development | cell-cell signaling | cell chemotaxis | molecular function regulator | metal ion homeostasis | blood vessel development | leukocyte migration | negative regulation of blood vessel diameter | regulation of nucleic acid-templated transcription | regulation of membrane potential | regulation of cellular response to stress | regulation of neurotransmitter levels | locomotion | positive regulation of response to cytokine stimulus | response to nitrogen compound | cellular response to hormone stimulus | positive regulation of reactive oxygen species biosynthetic process | response to nicotine | response to external biotic stimulus | system development | response to oxygen levels | reproductive process | regulation of signal transduction | positive regulation of urine volume | positive regulation of organelle organization | negative regulation of secretion by cell | positive regulation of icosanoid secretion | regulation of actin cytoskeleton organization | multicellular organism development | response to activity | cell migration | cellular response to peptide hormone stimulus | regulation of MAPK cascade | response to amino acid | positive regulation of organelle assembly | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | response to fatty acid | positive regulation of muscle organ development | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of actomyosin structure organization | regulation of granulocyte chemotaxis | regulation of phosphorylation | regulation of hormone levels | regulation of sensory perception of pain | regulation of hormone secretion | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | positive regulation of chemotaxis | rhythmic synaptic transmission | positive regulation of secretion | organic substance transport | response to ketone | cellular response to stress | response to lipid | nervous system process | cellular response to peptide | regulation of blood pressure | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | protein kinase C deactivation | animal organ morphogenesis | regulation of blood coagulation | cellular response to oxygen levels | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of JNK cascade | small molecule metabolic process | peptide transport | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of smooth muscle cell apoptotic process | response to oxidative stress | positive regulation of cell differentiation | regulation of endothelial cell migration | second-messenger-mediated signaling | stem cell differentiation | positive regulation of cell migration | fatty acid biosynthetic process | cellular response to cytokine stimulus | biosynthetic process | sensory perception of pain | regulation of cellular protein metabolic process | vasoconstriction | angiogenesis | cellular response to glucocorticoid stimulus | middle ear morphogenesis | lipid biosynthetic process | positive regulation of odontogenesis | inositol lipid-mediated signaling | response to toxic substance | regulation of systemic arterial blood pressure by endothelin | positive regulation of lipid localization | positive regulation of cell growth involved in cardiac muscle cell development | response to xenobiotic stimulus | regulation of heart contraction | cation homeostasis | cellular response to corticosteroid stimulus | regulation of leukocyte migration | sensory organ development | cellular response to drug | negative regulation of response to wounding | response to bacterium | regulation of muscle cell apoptotic process | chordate embryonic development | peptide secretion | cellular cation homeostasis | endocrine process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of smooth muscle contraction | response to testosterone | positive regulation of leukocyte chemotaxis | positive regulation of cytoskeleton organization | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | rhythmic excitation | heart development | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | protein kinase C-activating G-protein coupled receptor signaling pathway | regulation of cytokine-mediated signaling pathway | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of tube size | positive regulation of transport | cellular response to fatty acid | embryonic morphogenesis | response to prostaglandin F | regulation of mitotic cell cycle | carboxylic acid metabolic process | cellular response to mineralocorticoid stimulus | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | calcium-mediated signaling | multicellular organism reproduction | embryonic organ morphogenesis | positive regulation of heart rate | regulation of signaling receptor activity | maternal process involved in parturition | receptor regulator activity | positive regulation of organ growth | regulation of cardiac muscle hypertrophy | regionalization | positive regulation of protein modification process | regulation of growth | cellular response to calcium ion | response to organic substance | vein smooth muscle contraction | regulation of cardiac muscle tissue development | tissue morphogenesis | epithelial fluid transport | branching morphogenesis of an epithelial tube | regulation of pH | regulation of kinase activity | positive regulation of chemokine-mediated signaling pathway | response to antineoplastic agent | response to mechanical stimulus | regulation of animal organ morphogenesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | response to leptin | phosphatidylinositol 3-kinase signaling | anatomical structure development | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | cell surface receptor signaling pathway | regulation of vasoconstriction | metabolic process | positive regulation of cell development | regulation of receptor biosynthetic process | mesenchymal cell differentiation | positive regulation of supramolecular fiber organization | regulation of neutrophil migration | response to mineralocorticoid | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | positive regulation of neutrophil chemotaxis | regulation of tube diameter | ear development | amide transport | negative regulation of muscle cell apoptotic process | chemical homeostasis | prostaglandin metabolic process | regulation of secretion | body fluid secretion | membrane depolarization | receptor ligand activity | immune response | hormone transport | positive regulation of muscle contraction | positive regulation of cellular component biogenesis | cytokine activity | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | nitric oxide transport | regulation of glucose transmembrane transport | animal organ development | positive regulation of ion transport | response to reactive oxygen species | negative regulation of cellular protein metabolic process | positive regulation of leukocyte migration | positive regulation of kinase activity | ion homeostasis | positive regulation of prostaglandin-endoperoxide synthase activity | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | cellular response to steroid hormone stimulus | phospholipase C-activating G-protein coupled receptor signaling pathway | renal system process | fatty acid metabolic process | positive regulation of organic acid transport | positive regulation of muscle tissue development | response to interferon-gamma | regulation of JNK cascade | positive regulation of endothelial cell migration | cell activation | positive regulation of MAPK cascade | drug transport | stem cell development | morphogenesis of a branching epithelium | regulation of reactive oxygen species biosynthetic process | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | sensory perception | regulation of epithelial cell migration | positive regulation of cardiac muscle cell differentiation | positive regulation of cytokine-mediated signaling pathway | icosanoid metabolic process | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of response to wounding | regulation of stress-activated MAPK cascade | multicellular organism aging | regulation of cell communication | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | cell development | regulation of developmental growth | organic acid metabolic process | positive regulation of phosphorylation | regulation of cell size | morphogenesis of a branching structure | anatomical structure morphogenesis | cation transport | positive regulation of MAP kinase activity | regulation of organ growth | response to biotic stimulus | ammonium transport | regulation of developmental process | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | regulation of muscle cell differentiation | positive regulation of anion transport | cellular response to interleukin-1 | positive regulation of cell cycle process | regulation of cell growth | positive regulation of cell size | negative regulation of coagulation | positive regulation of prostaglandin secretion | response to salt | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | innate immune response | neurotransmitter transport | regulation of fatty acid transport | positive regulation of nucleic acid-templated transcription | signal release | positive regulation of heart growth | response to organonitrogen compound | prostaglandin biosynthetic process | neural crest cell differentiation | positive regulation of granulocyte chemotaxis | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | regulation of anion transport | positive regulation of nitric oxide biosynthetic process | positive regulation of JUN kinase activity | response to calcium ion | negative regulation of blood coagulation | in utero embryonic development | positive regulation of metabolic process | regulation of actin filament-based process | ion transport | skeletal system development | positive regulation of lipid transport | immune system process | cellular metabolic process | positive regulation of receptor biosynthetic process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | positive regulation of cardiac muscle tissue development | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to steroid hormone | regulation of organelle assembly | negative regulation of cell death | neutrophil migration | circulatory system development | aging | chemotaxis | ear morphogenesis | divalent inorganic cation homeostasis | neural crest cell development | regulation of cellular component organization | regulation of cytoskeleton organization | muscle system process | response to other organism | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of fatty acid transport | positive regulation of gene expression | response to glucocorticoid | cellular response to growth factor stimulus | regulation of muscle organ development | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | clathrin-coated vesicle | cytoplasmic vesicle | basal part of cell | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | secretory vesicle | endomembrane system | vesicle | transport vesicle | endoplasmic reticulum lumen | rough endoplasmic reticulum lumen | extracellular region | membrane-bounded organelle | organelle | extracellular space | membrane-enclosed lumen | Weibel-Palade body | rough endoplasmic reticulum | intracellular vesicle | intracellular | coated vesicle

PATHWAYS

PID_ENDOTHELIN_PATHWAY | REACTOME_GPCR_LIGAND_BINDING | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | REACTOME_SIGNALING_BY_GPCR | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | PID_HIF1_TFPATHWAY | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK | PID_AP1_PATHWAY | REACTOME_GPCR_DOWNSTREAM_SIGNALING

PROTEIN FAMILY

Endothelin-like toxin | Endothelin-like toxin, conserved site | Endothelin