QuickView for fibulin 1 (gene)

Gene Symbol:

FBLN1 Homo sapiens

Full name:

fibulin 1

Synonyms:

FBLN, FIBL1, fibulin-1

Genomic Location:

Chr 22: 44277383-44375678

Description:

Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isofo...

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Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

COUP_01 ,  TGACCTY_ERR1_Q2 ,  HNF4_DR1_Q3 ,  DR1_Q3 ,  COUP_DR1_Q6 ,  CTTTGT_LEF1_Q2 ,  HNF4_01_B

Cytogenetic Map:

22q13.31

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