Name: | Folic Acid Antagonists |
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Description: | Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) |
Synonyms: |
Antifolates; Acid Antagonists, Folic; Antagonists, Folic Acid
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