QuickView for follistatin (gene)

Gene Symbol:

FST Homo sapiens

Full name:

follistatin

Synonyms:

FS, follistatin, activin-binding protein, follistatin isoform FST317

Genomic Location:

Chr 5: 52812352-52817680

Description:

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and a...

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Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  FREAC7_01 ,  TGANTCA_AP1_C ,  CEBPA_01 ,  RSRFC4_01 ,  FOXO4_01 ,  SRF_Q6 ,  FOXD3_01 ,  HFH1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  STAT6_01 ,  AMEF2_Q6 ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  MYB_Q5_01 ,  TTAYRTAA_E4BP4_01 ,  TCF4_Q5 ,  WTGAAAT_UNKNOWN ,  OSF2_Q6 ,  TCTAGAG_MIR517 ,  TATAAA_TATA_01 ,  AR_Q6 ,  CEBP_Q2 ,  SOX9_B1 ,  LEF1_Q6 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  STAT5A_03 ,  CEBPB_02 ,  SRF_Q4 ,  GATA6_01 ,  GCGNNANTTCC_UNKNOWN ,  S8_01 ,  FOXO1_01 ,  RAAGNYNNCTTY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  SPZ1_01 ,  SOX5_01 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  AP2_Q6 ,  MTF1_Q4 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  AAAYRNCTG_UNKNOWN ,  GATA4_Q3 ,  WTTGKCTG_UNKNOWN ,  CTGAGCC_MIR24 ,  CTGCAGY_UNKNOWN ,  TCCATTKW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  SRY_02 ,  AACTTT_UNKNOWN ,  ER_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-330

Cytogenetic Map:

5q11.2

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