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QuickView for follitropin beta (compound)
PubChem Substance
| Name: | Follicle Stimulating Hormone, beta Subunit |
|---|---|
| PubChem Substance ID: | 17398106 |
| Description: | The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility. |
| Synonyms: |
Follistim; Follitropin beta (genetical recombination); 110909-60-9; Follistim (TN); D04430; Follitropin beta; Follitropin beta (genetical recombination) (JAN)
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DrugBank
Identification
| Name: | Follicle Stimulating Hormone, beta Subunit |
|---|---|
| Name (isomeric): | DB00066 |
| Drug Type: | biotech |
| Description: | The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility. |
| Synonyms: |
FSH-B; Follitropin beta chain precursor; Follitropin alfa/beta; Follicle-stimulating hormone beta subunit; FSH-beta
|
| Brand: | Follistim (Organon), Gonal-F, Gonal F |
| Category: | Fertility Agents |
| CAS number: | 9002-68-0 |
Pharmacology
| Indication: | For treatment of female infertility |
|---|---|
| Pharmacology: | Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development. |
| Mechanism of Action: |
Follitropin alpha is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which i...
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| Half Life: | 2-5 hrs |
| Clearance: | 0.01 1*h-1kg-1 [European women with a single intramuscular dose of 300 IU] 0.01 1*h-1kg-1 [Japanese women with a single intramuscular dose of 300 IU] |
| Affected organisms: | Humans and other mammals |
Targets
