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QuickView for gephyrin (gene)


Gene Symbol:
GPHN Homo sapiens Homo sapiens
Full name:
gephyrin
Synonyms:
GEPH, GPH, GPHRYN, HKPX1, MOCODC, gephyrin
Genomic Location:
Chr 14: 66043878-66718278
Description:
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 14
14q23.3-q24.1





GO Molecular Function

cofactor binding | cation binding | ribonucleotide binding | nucleotide binding | nitrate reductase activity | coenzyme binding | carbohydrate derivative binding | nucleotidyltransferase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | molybdopterin cofactor binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | molybdopterin molybdotransferase activity | transferase activity, transferring phosphorus-containing groups | adenylyltransferase activity | oxidoreductase activity, acting on other nitrogenous compounds as donors | molybdopterin adenylyltransferase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

purine ribonucleotide metabolic process | glycine receptor clustering | response to metal ion | membrane organization | cellular process | localization | neurotransmitter-gated ion channel clustering | nucleotide metabolic process | ribose phosphate metabolic process | macromolecule localization | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | response to inorganic substance | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | nitrate reductase activity | purine nucleotide metabolic process | establishment of synaptic specificity at neuromuscular junction | molybdopterin cofactor biosynthetic process | postsynaptic neurotransmitter receptor diffusion trapping | receptor clustering | cellular localization | cellular nitrogen compound metabolic process | cofactor metabolic process | protein modification process | cellular biosynthetic process | purine nucleoside metabolic process | macromolecule modification | nitrogen compound metabolic process | coenzyme biosynthetic process | phosphorus metabolic process | localization within membrane | protein localization to membrane | organophosphate metabolic process | nucleoside metabolic process | neuromuscular junction development | cofactor biosynthetic process | small molecule metabolic process | synapse organization | nucleobase-containing small molecule metabolic process | gamma-aminobutyric acid receptor clustering | biosynthetic process | phosphate-containing compound metabolic process | molybdenum incorporation into molybdenum-molybdopterin complex | receptor localization to synapse | GTP metabolic process | protein-containing complex localization | postsynaptic membrane organization | protein metabolic process | metabolic process | oxidation-reduction process | cellular protein localization | oxidoreductase activity, acting on other nitrogenous compounds as donors | nucleobase-containing compound metabolic process | organic substance metabolic process | protein localization | cellular protein metabolic process | cellular macromolecule localization | cellular protein modification process | carbohydrate derivative metabolic process | Mo-molybdopterin cofactor biosynthetic process | heterocycle metabolic process | cellular metabolic process | oxidoreductase activity | molybdopterin cofactor metabolic process | macromolecule metabolic process

GO Cellular Component

dendrite | synapse | neuron projection | somatodendritic compartment | cell | synaptic membrane | cytoplasm | intracellular organelle | dendritic tree | cell projection | postsynaptic membrane | postsynapse | plasma membrane | organelle | postsynaptic specialization | cell periphery | cytosol | cytoskeleton | intracellular | cell junction | membrane