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QuickView for guaifenesin (compound)

Summary
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PubChem

PubChem Compound 3516

PubChem Compound 3516

Name:	Guaifenesin
PubChem Compound ID:	3516
Description:	An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Molecular formula:	C₁₀H₁₄O₄
Molecular weight:	198.216 g/mol
Synonyms:	Glycerol mono(2-methoxyphenyl)ether; MLS000028402; Glycerol alpha-(o-methoxyphenyl)ether; Glycerol .alpha.-(o-methoxyphenyl)ether; Tussar-2; Mintosyl; 1,2-Propanediol, 3- (2-methoxyphenoxy)-; Naldecon-DX; Metossipropandiolo; Hycotuss. show more » Glycerol mono(2-methoxyphenyl)ether; MLS000028402; Glycerol alpha-(o-methoxyphenyl)ether; Glycerol .alpha.-(o-methoxyphenyl)ether; Tussar-2; Mintosyl; 1,2-Propanediol, 3- (2-methoxyphenoxy)-; Naldecon-DX; Metossipropandiolo; Hycotuss; Trecid; Guaicol glycerine ether; Metfenossidiolo; Glycotuss; Naldecon-CX; Hustosil; Guaiamar; Tussi-Organidin DM NR; Mucinex; Guaifenesina [INN-Spanish]; Robitussin DM; Isoclor Expectorant C; Guaifenesin (JP15/USP); Dilor G; Prestwick_231; Guaiacolglicerinetere; Dilyn; GLYCERYL GUAIACOLATE; Miocaina; Coricidin Syrup; Guiaphenesin; Robitussin CF; Hustodil; KBio1_000248; XL-90; Guaifenesine [INN-French]; Sudafed Cough Syrup; Amonidrin; Spectrum3_000444; KBioSS_001315; Guaiphenesine; Glycerol alpha-monoguaiacol ether; Guaiacuran; Breonesin; Ru-Tuss Expectorant; Tenntuss; Muskurelax; Robitussin Cold & Cough; Gnaifenesin; Glyceryl guaiacyl ether; Triaminic; Tulyn; Propanosedyl; Glycerol mono(2-methoxyphenyl) ether; NSC 62112; Component of Trind-DM; Respil; Myocain; Glyceryl guaiacolate ether; Tussi-organidin NR; Glycerol alpha-(2-methoxyphenyl) ether; Neuroton; Glycerol .alpha.-monoguaiacol ether; Spectrum4_000566; Glycerol alpha-guaiacyl ether; Reorganin; SMR000058387; Polaramine Expectorant; Prestwick0_000776; SPBio_002791; o-Methoxyphenyl glyceryl ether; Glycero-guaiacol ether; Guajacol-glycerinaether; Entex; Glycerol-alpha-guajakolether [Czech]; Lufyllin-GG; Hustosil (TN); (component of) Deconsal II; Oresol; 3-(2-Methoxyphenoxy)-1,2-propanediol; Guaia-rom; Oreson; Tolyn; 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane; Creson; D00337; NINDS_000248; Neothylline-GG; Tussi-Organidin DM-S NR; Respenyl; Glycerol alpha-guiacyl ether; Glycerin guaiacolate; Methoxypropanediol; Component of Quibron; Mucinex D; Myocaine; Tulyl; Neurotone; Guanar; Glycerol alpha-(o-methoxyphenyl) ether; Guaiphesin; Glyc; Hytuss; Naldecon-EX; Glycerin monoguaiacol ether; SPBio_001208; Component of Brondecon; Component of Colrex Expectorant; 93-14-1; Congestac; Guaifenesinum [INN-Latin]; DivK1c_000248; Mucostop; Glyceryl guaicolate; DRG-0160; .Alpha.-Glyceryl guaiacol ether; 4-06-00-05576 (Beilstein Handbook Reference); Guaiacolic acid, ester with glycerol; Resil; Contac Cough & Sore Throat Formula; Histalet X Tablets; Robitussin Severe Congestion; Tussar SF; AIDS-125111; Guaiacyl glyceryl ether; Aether glycerinoguaiacolicus; Sudafed Cold and Cough; Guaianesin; Resyl; Guajacol-alpha-glycerinether; Myorelax; Kwelcof; EINECS 202-222-5; Dorassin; Tolseron; Miocurin; Slo-Phyllin GG; Brexin EX; Miorelax; Glycerinmonoguaiacol ether; Calmipan; Ru-Tuss DE Tablets; My 301; 3-(o-Methoxyphenoxy)-propanediol-1,2; Relaxyl-G; Methphenoxydiol; Tedral Expectorant; Spectrum2_001104; KBio3_001308; Brondecon; KBio2_003883; KBioGR_000972; Component of Hycotuss; G 87; Guajacuran; Spectrum_000835; 128707-44-8; 12041-73-5; BRN 2049375; 1336-67-0; 1,2-Propanediol, 3-(2-methoxyphenoxy)-; GGE; Dimacol; GGG; 2-G; Sirotol; 3-o-Methoxyphenoxypropane 1:2-diol; Guaifenesin; Guaifenesin [USAN:INN:JAN]; Guaiphenesin; Reduton; 1,2-Propanediol, 3-(o-methoxyphenoxy)-; Aeronesin; alpha-Glyceryl guaiacolate ether; Glyceryl guaiacol ether; 3-(o-Methoxyphenoxy)-1,2-propanediol; Robitussin; 3-(2-Methoxyphenoxy)-1, 2-propanediol; KBio2_006451; Glyceryl guaiacol; Organidin NR; Guaicol glyceryl ether; Guajamar; Guaiacol glycerol ether; Myoscaine; Nasatab LA; 2/G; Guajacol-.alpha.-glycerin-ether; AI3-24947; Glycerylguaiacol; Glycerol .alpha.-guiacyl ether; MY-301; Robitussin (TN); 1,2-Propanediol, 3- (o-methoxyphenoxy)-; Flartussin; Ritussin; Guaiacol glyceryl ether; Aresol; Component of Trind; SL-90; AIDS125111; PV Tussin Tablet; Cortussin; Tussi-Organidin-S NR; Guayanesin; Myoscain; alpha-Glyceryl guaiacol ether; Relaxil G; Robitussin PE; Pneumomist; Gaiamar; Guaiacurane; Glycerol .alpha.-(2-methoxyphenyl) ether; Guajacol-glycerinaether [German]; NSC62112; Bayer Select Head & Chest Cold; Bronkaid Caplets; Guaiacol glycerin ether; 1,2,3-Propanetriol, ether with 2-methoxyphenol; KBio2_001315; Bronchol; Contac Cough Formula; Pneumotussin HC; Theolair Plus; Glycerol-alpha-monoguaiacol ether; Gvaja; HSDB 3089; Prestwick1_000776; Glyceryl guiacolate; Glycerol .alpha.-guaiacyl ether; .Alpha.-Glyceryl guaiacolate ether; Component of Quibron Plus; Glycerol guaiacolate show less «

DrugBank

Identification

Name:	Guaifenesin
Name (isomeric):	DB00874
Drug Type:	small molecule
Description:	An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Synonyms:	Guiaphenesin; Glycerin guaiacolate; Methoxypropanediol; Glyceryl guaiacol ether; Methphenoxydiol; Glyceryl guaicolate; Glyceryl guaiacolate ether; Metfenossidiolo; Glyceryl guaiacyl ether; Glycerin monoguaiacol ether. show more » Guiaphenesin; Glycerin guaiacolate; Methoxypropanediol; Glyceryl guaiacol ether; Methphenoxydiol; Glyceryl guaicolate; Glyceryl guaiacolate ether; Metfenossidiolo; Glyceryl guaiacyl ether; Glycerin monoguaiacol ether; Metossipropandiolo; Glyceryl guiacolate; o-Methoxyphenyl glyceryl ether; Glyceryl guaiacol; Glycero-guaiacol ether; Glyceryl guaiacolate; Glycerol guaiacolate show less «
Brand:	Guiatuss, Miocaina, Scot-tussin Expectorant, Guaiphenesin, Guaiacol glycerin ether, Dilyn, Equicol, Humibid Sprinkle, Neurotone, Actifed-C, Flartussin, Guaiphenesine, Hustosil, Diabetic Tussin EX, Hytuss, Guaicol glyceryl ether, Guaiphesin, Naldecon Senior EX, Guayanesin, Guaiacuran, Creson, Guaianesin, Hustodil, Guaiacolglicerinetere, Guaiamar, Robitussin, Neuroton, Miorelax, Myorelax, Guaiacyl glyceryl ether, Bronchol, Miocurin, Uni-tussin, Guaiacol glyceryl ether, Glytuss, Sinumist-SR, Cortussin, Amonidren, Genatuss, Resyl, Tolseron, Respil, Glycotuss, Resil, Mintosyl, Guajacol-glycerinaether, Hytuss-2X, Touro EX, Myoscain, Fenesin, Reorganin, Mucostop, Balminil Expectorant, Tenntuss, Gvaja, Myoscaine, Tolyn, Anti-Tuss, Tulyn, Ritussin, Reduton, Guaiacol glycerol ether, Myocain, Halotussin, Aeronesin, Organidin NR, Benylin-E, Gaiamar, Glycodex, Relaxil G, Tenntus, Myocaine, Guaia-rom, Gnaifenesin, Muskurelax, Guaicol glycerine ether, Respenyl, Pneumomist, Propanosedyl, Calmipan, Humibid L.A, Amonidrin, Sirotol, Guanar, Mucinex, Tulyl, Guajamar, Calmylin Expectorant, Relaxyl-G, Guajacuran, Oreson, Breonesin, Oresol, Gee-Gee, Dorassin, Guaiacurane, Aresol, Colrex expectorant
Brand name mixture:	Tri-Anamine Expect Antihist Decong Syrup(Guaifenesin + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate), Entex La(Guaifenesin + Phenylpropanolamine Hydrochloride), Novahistex Dm Expectorant with Decongestant(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cough Syrup Dm Expectorant(Dextr... show more » Tri-Anamine Expect Antihist Decong Syrup(Guaifenesin + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate), Entex La(Guaifenesin + Phenylpropanolamine Hydrochloride), Novahistex Dm Expectorant with Decongestant(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cough Syrup Dm Expectorant(Dextromethorphan Hydrobromide + Guaifenesin), Koffex Dm + Decongestant + Expectorant(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cough Syrup Dm-E(Dextromethorphan Hydrobromide + Guaifenesin), Cough Syrup Dm-D-E(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Dm-D-Expectorant Cough and Cold Syrup(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cough Syrup Dm Decongestant Expectorant(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Sudafed Cold and Flu Gel Caps(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Calmylin Cough and Flu Liq(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Dimetane Expectorant-Dc Syr(Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride), Creo Grippe Enfants Sup(Camphor + Eucalyptol + Guaifenesin), Benylin 4 Flu - Syrup(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cough Syrup W.Guaifenesin W.Dextromethorphan(Dextromethorphan Hydrobromide + Guaifenesin), Bronchodex Pediatrique(Dextromethorphan Hydrobromide + Guaifenesin + Pheniramine Maleate + Pseudoephedrine Hydrochloride), Calmylin #3 Syr(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Broncho Tuss Adult(Guaifenesin + L-Ephedrine Hydrochloride + Sodium Camsylate), Creo Grippe Sup Adultes(Camphor + Eucalyptol + Guaifenesin), Entex La Tablets Srt(Guaifenesin + Phenylpropanolamine Hydrochloride), Cold Aid for Birds(Ammonium Chloride + Glycerine + Guaifenesin + Oil of Anise + Sodium Bicarbonate), Dm Expectorant Cough Syrup(Dextromethorphan Hydrobromide + Guaifenesin), Ephedrine Ii with Guaifenesin(Ephedrine Racemic (Ephedrine Hydrochloride) + Guaifenesin), Dayquil Liquicaps(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Novahistex Expectorant with Decongestant(Guaifenesin + Pseudoephedrine Hydrochloride), Novahistine Dm Expectorant with Decongestant(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Triaminic Decongest+Expect Liqui-Gels Cap(Guaifenesin + Pseudoephedrine Hydrochloride), Triaminic Expectorant Dh Syrup(Guaifenesin + Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate), Pulmosirum Plus Expectorant(Ammonium Chloride + Beechwood Creosote + Cocillana + Eucalyptus Oil + Guaiacol + Guaifenesin + Ipecac + Lobelia Inflata + Menthol + Myroxylon Balsamum + White Pine), Daytime Cold & Flu Liquid Capsules(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Ephedrine V with Guaifenesin(Ephedrine Hydrochloride + Guaifenesin), Cough and Flu Syrup(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cough Syrup Dm-Expectorant(Dextromethorphan Hydrobromide + Guaifenesin), I D M Expectorant Tab(Guaifenesin + Potassium Iodide + Pyrilamine Maleate + Theophylline), Nezger Tab(Acetylsalicylic Acid + Diphenylpyraline Hydrochloride + Guaifenesin + Phenylephrine Hydrochloride), I.D.M. Solution(Guaifenesin + L-Ephedrine Hydrochloride + Potassium Iodide + Pyrilamine Maleate), Ornade Expectorant Cough Formula(Chlorpheniramine Maleate + Guaifenesin + Phenylpropanolamine Hydrochloride), Koffex Dm + Expectorant Extra Strength(Dextromethorphan Hydrobromide + Guaifenesin), Centracol Pediatrique - Syr(Dextromethorphan Hydrobromide + Guaifenesin + Pheniramine Maleate + Pseudoephedrine Hydrochloride), Dm Plus Decongestant Plus Expectorant Cough Syrup(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Babys Own Cough Syr(Ammonium Chloride + Guaifenesin + Pyrilamine Maleate), Vicks Cough Syrup New Improved(Carbetapentane Citrate + Ephedrine + Guaifenesin), Pharmitussin Dm(Dextromethorphan Hydrobromide + Guaifenesin), Calmylin Codeine D-E Syr(Codeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride), Koffex Dm + Expectorant(Dextromethorphan Hydrobromide + Guaifenesin), Pulmorex Expectorant Liq(Ammonium Chloride + Diphenhydramine Hydrochloride + Guaifenesin), Dymetadrine 25 - Tab(Ephedrine Hydrochloride + Guaifenesin), Novahistex Dh Expectorant(Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride), Regular Strength Tylenol Cold Chest Congestion(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Dm Cough Syrup Expectorant(Dextromethorphan Hydrobromide + Guaifenesin), Daytime Liquid - Liq(Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Koffex Dm-D-E - Liq(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Benylin Codeine 3.3mg de Syr(Codeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride), Dimetane Expectorant-C Syr(Brompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride), Cough Syr W.Cod. Pseudoephed.Hcl Guaifenesin(Codeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride), Triaminic Expectorant Syr(Chlorpheniramine Maleate + Guaifenesin + Pseudoephedrine Hydrochloride), Dm Plus Expectorant Syrup(Dextromethorphan Hydrobromide + Guaifenesin), Robitussin Syrup with Codeine(Codeine Phosphate + Guaifenesin + Pheniramine Maleate), Mielocol Syrup(Aralia Racemosa + Eucalyptol + Guaifenesin + Honey + Poplar Bud + Sanguinaria Canadensis + White Pine + Wild Cherry), Broncho Tuss Infant(Guaifenesin + L-Ephedrine Hydrochloride + Sodium Camsylate), Triaminic Dm Daytime Syr(Dextromethorphan Hydrobromide + Guaifenesin + Phenylpropanolamine Hydrochloride), Cold and Respiratory Aid for Hamsters(Ammonium Chloride + Glycerine + Guaifenesin + Oil of Anise + Sodium Bicarbonate), Koffex Dm + Decongestant + Expectorant Extra Strength(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Cheracol Cough Syrup(Alcohol Anhydrous + Ammonium Chloride + Codeine Phosphate + Guaifenesin), Dimetane Expectorant Liq(Brompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride), Triaminic Dm Expectorant Syr(Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Dm Plus Decongestant Plus Expector.Ex.St.Syr(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Tussin Cough Medicine Dm Antitussive Expectorant Decongestant(Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride), Guaiacol Plus Pwr(Ammonium Chloride + Guaifenesin + Potassium Iodide), Quiex-K1 Syr(Aminophylline + Guaifenesin + Potassium Iodide) show less «
Category:	Expectorants
CAS number:	93-14-1

Pharmacology

Indication:	Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Pharmacology:	Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of... show more » Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway. show less «
Mechanism of Action:	Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the... show more » Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing. show less «
Absorption:	Rapidly absorbed from the GI tract
Biotransformation:	Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
Half Life:	1 hour
Toxicity:	LD₅₀ 1510 mg/kg (rat, oral)
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Take without regard to meals.

Take with a full glass of water.