QuickView for heat shock protein hsp90 (gene)
- Gene Symbol:
- HSP90AB1
Homo sapiens - Full name:
- heat shock protein 90 alpha family class B member 1
- Synonyms:
- D6S182, HSP84, HSP90B, HSPC2, HSPCB, heat shock protein HSP 90-beta, HSP90-beta, heat shock 84 kDa, heat shock 90kD protein 1, beta, heat shock protein 90 kDa, heat shock protein 90kDa alpha (cytosolic), class B member 1, heat shock protein 90kDa alpha family class B member 1
- Genomic Location:
- Chr 6: 44322827-44329592
- Description:
-
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing ...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
6p21.1
| Transcripts Names |
|---|
| NM_007355 |
| NR_073528 |
| NM_001271972 |
| NM_001271969 |
| NM_001271971 |
| NM_001271970 |
| XM_024446421 |
GO Molecular Function
kinase binding | protein kinase regulator activity | guanyl ribonucleotide binding | ribonucleoside binding | peptide binding | cadherin binding | kinase regulator activity | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | DNA polymerase binding | disordered domain specific binding | nucleotide binding | ATP-dependent protein binding | signaling receptor binding | hydrolase activity | pyrimidine ribonucleotide binding | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | CTP binding | histone methyltransferase binding | molecular function regulator | catalytic activity | ion channel binding | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | tau protein binding | ATPase activity, coupled | sulfonylurea receptor binding | amide binding | purine nucleotide binding | identical protein binding | adenyl deoxyribonucleotide binding | TPR domain binding | MHC class II protein complex binding | ion binding | organic cyclic compound binding | purine nucleoside binding | UTP binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity | GTP binding | nitric-oxide synthase regulator activity | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | dATP binding | drug binding | heat shock protein binding | histone deacetylase binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | pyrimidine nucleotide binding | small molecule binding | RNA binding | double-stranded RNA binding
GO Biological Process
positive regulation of immune response | cell morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | regulation of dephosphorylation | regulation of intracellular protein transport | exocytosis | response to cytokine | neuron projection morphogenesis | immune response-regulating signaling pathway | neutrophil activation | developmental process involved in reproduction | regulation of cellular localization | protein stabilization | regulation of localization | protein kinase regulator activity | regulation of programmed cell death | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | positive regulation of phosphoprotein phosphatase activity | regulation of nitric oxide biosynthetic process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | regulation of phosphatase activity | regulation of protein import | cell differentiation | immune response-activating cell surface receptor signaling pathway | nervous system development | response to drug | cell part morphogenesis | positive regulation of tau-protein kinase activity | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | virion attachment to host cell | regulation of response to interferon-gamma | negative regulation of proteolysis | regulation of neuron death | positive regulation of dephosphorylation | neuron projection extension | positive regulation of cellular biosynthetic process | cellular process | telomere maintenance via telomerase | secretion | Fc-gamma receptor signaling pathway involved in phagocytosis | leukocyte degranulation | central nervous system neuron axonogenesis | localization | cell projection morphogenesis | negative regulation of ubiquitin-dependent protein catabolic process | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | kinase regulator activity | positive regulation of reactive oxygen species metabolic process | central nervous system neuron differentiation | reproductive system development | positive regulation of telomerase activity | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | negative regulation of apoptotic process | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell cycle arrest | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of complement-dependent cytotoxicity | anatomical structure homeostasis | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | xenobiotic metabolic process | positive regulation of cyclin-dependent protein kinase activity | regulation of interferon-gamma-mediated signaling pathway | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | response to topologically incorrect protein | cellular aromatic compound metabolic process | establishment of cell polarity | cellular component organization | viral life cycle | negative regulation of cellular protein catabolic process | positive regulation of protein binding | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | neutrophil degranulation | regulation of cellular response to heat | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to cocaine | response to salt stress | cellular response to xenobiotic stimulus | response to stress | leukocyte activation involved in immune response | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | positive regulation of phosphatase activity | supramolecular fiber organization | reproduction | secretion by cell | cellular nitrogen compound metabolic process | telomere organization | immune response-activating signal transduction | cellular response to organic cyclic compound | regulation of protein transport | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | cellular component assembly | regulation of peptide transport | cellular biosynthetic process | telomere maintenance via telomere lengthening | positive regulation of protein dephosphorylation | regulation of intracellular transport | molecular function regulator | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | negative regulation of neuron apoptotic process | central nervous system neuron development | positive regulation of reactive oxygen species biosynthetic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of protein stability | multicellular organism development | regulation of tau-protein kinase activity | leukocyte mediated immunity | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of protein localization to cell surface | regulation of phosphorylation | telomerase holoenzyme complex assembly | adhesion of symbiont to host | Fc-gamma receptor signaling pathway | positive regulation of cell cycle | DNA biosynthetic process | positive regulation of protein localization to cell surface | axon development | positive regulation of intracellular protein transport | RNA-dependent DNA biosynthetic process | negative regulation of cytokine production | regulation of protein import into nucleus, translocation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | response to ammonium ion | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | vesicle-mediated transport | axonogenesis | positive regulation of hydrolase activity | positive regulation of cell differentiation | cellular response to cytokine stimulus | positive regulation of protein localization to nucleus | biosynthetic process | response to osmotic stress | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulated exocytosis | cellular protein-containing complex assembly | regulation of complement-dependent cytotoxicity | response to xenobiotic stimulus | cell morphogenesis involved in differentiation | establishment or maintenance of cell polarity | cellular response to drug | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | positive regulation of DNA biosynthetic process | cell activation involved in immune response | adhesion of symbiont to host cell | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | positive regulation of transport | viral process | regulation of cellular response to growth factor stimulus | positive regulation of molecular function | regulation of nucleocytoplasmic transport | negative regulation of transforming growth factor beta production | regulation of proteasomal ubiquitin-dependent protein catabolic process | neuron differentiation | cellular response to interleukin-4 | protein-containing complex assembly | activation of immune response | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | negative regulation of transforming growth factor beta activation | regulation of protein import into nucleus | regulation of protein dephosphorylation | regulation of kinase activity | DNA metabolic process | import into cell | chaperone-mediated protein complex assembly | axon extension | regulation of intracellular signal transduction | anatomical structure development | developmental growth involved in morphogenesis | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | nitric-oxide synthase regulator activity | endocytosis | immune response | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | protein folding | regulation of type I interferon-mediated signaling pathway | animal organ development | negative regulation of cellular protein metabolic process | ribonucleoprotein complex assembly | positive regulation of kinase activity | regulation of phosphate metabolic process | response to alkaloid | positive regulation of binding | positive regulation of intracellular transport | cell activation | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | positive regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein import into nucleus, translocation | regulation of cell communication | signaling | regulation of protein binding | response to organic cyclic compound | cell development | positive regulation of phosphorylation | regulation of cell size | enzyme regulator activity | response to unfolded protein | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of protein import into nucleus | reproductive structure development | regulation of developmental process | regulation of phosphoprotein phosphatase activity | positive regulation of DNA metabolic process | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of protein import | Fc receptor signaling pathway | positive regulation of cell size | Fc receptor mediated stimulatory signaling pathway | regulation of transport | regulation of reactive oxygen species metabolic process | developmental cell growth | neutrophil mediated immunity | response to organonitrogen compound | heterocycle metabolic process | positive regulation of nitric oxide biosynthetic process | central nervous system development | response to anesthetic | positive regulation of metabolic process | chromosome organization | ribonucleoprotein complex biogenesis | immune system process | cellular metabolic process | negative regulation of cell cycle process | placenta development | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | negative regulation of proteolysis involved in cellular protein catabolic process | positive regulation of nucleocytoplasmic transport | phagocytosis | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | response to interleukin-4 | negative regulation of proteasomal protein catabolic process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | brush border | dendrite | intracellular membrane-bounded organelle | apical plasma membrane | neuron projection | somatodendritic compartment | organelle membrane | cell projection membrane | cytoplasmic vesicle | COP9 signalosome | cell body | cell | nuclear lumen | neuronal cell body | distal axon | dendrite terminus | transcription factor complex | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | receptor complex | brush border membrane | dendritic tree | ficolin-1-rich granule lumen | apical part of cell | melanosome | inclusion body | protein-containing complex | cell projection | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane | sperm head plasma membrane | aryl hydrocarbon receptor complex | vacuole | vesicle | perinuclear region of cytoplasm | extracellular exosome | mitochondrion | site of polarized growth | sperm plasma membrane | lytic vacuole | axonal growth cone | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | cell periphery | axon | membrane-enclosed lumen | basolateral plasma membrane | growth cone | secretory granule lumen | ooplasm | cytosol | intracellular vesicle | cell surface | dendritic growth cone | intracellular | lysosomal membrane | membrane | vesicle lumen | sperm head | vacuolar membrane
