QuickView for hmgb1 (gene)
- Gene Symbol:
- HMGB1
Homo sapiens - Full name:
- high mobility group box 1
- Synonyms:
- HMG-1, HMG1, HMG3, SBP-1, high mobility group protein B1, Amphoterin, Sulfoglucuronyl carbohydrate binding protein, high-mobility group (nonhistone chromosomal) protein 1
- Genomic Location:
- Chr 13: 29930877-29938081
- Description:
-
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogene...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_05 , SMTTTTGT_UNKNOWN , TTTGCAG_MIR518A2 , SMAD3_Q6 , CATTGTYY_SOX9_B1 , AREB6_04 , E2F1_Q4 , COMP1_01 , SOX9_B1 , GGATTA_PITX2_Q2
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-129 , Predicted Gene Targets for miR-142-3p , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-205 , Predicted Gene Targets for miR-216 , Predicted Gene Targets for miR-218 , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-450 , Predicted Gene Targets for miR-410
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
13q12.3
| Transcripts Names |
|---|
| NM_002128 |
| XM_024449343 |
| NM_001313893 |
| XM_024449340 |
| XM_024449344 |
| NM_001313892 |
| XM_024449341 |
| XM_024449342 |
GO Molecular Function
cytokine binding | modified amino acid binding | repressing transcription factor binding | DNA secondary structure binding | C-X-C chemokine binding | enzyme binding | nucleic acid binding | protein-containing complex binding | DNA polymerase binding | lipid binding | four-way junction DNA binding | signaling receptor binding | supercoiled DNA binding | single-stranded DNA binding | carbohydrate derivative binding | phospholipid binding | lyase activity | chemokine binding | molecular function regulator | catalytic activity | anion binding | DNA binding | damaged DNA binding | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | DNA binding, bending | protein binding | receptor regulator activity | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | phosphatidylserine binding | lipopolysaccharide binding | receptor ligand activity | cytokine activity | chemoattractant activity | bubble DNA binding | heterocyclic compound binding | RAGE receptor binding | RNA binding
GO Biological Process
positive regulation of immune response | negative regulation of lymphocyte differentiation | leukocyte homeostasis | negative regulation of leukocyte activation | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | regulation of T cell mediated immunity | adaptive immune response | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | negative regulation of immune system process | exocytosis | CD4-positive, alpha-beta T cell differentiation | cell motility | CD4-positive, alpha-beta T cell activation | immune response-regulating signaling pathway | neutrophil activation | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | negative regulation of phagocytosis | establishment of localization | regulation of autophagy | regulation of immune system process | neutrophil homeostasis | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | cell differentiation | positive regulation of epithelial cell proliferation | regulation of T cell differentiation | defense response | nervous system development | cellular chemical homeostasis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | regulation of DNA repair | tumor necrosis factor secretion | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | secretion | toll-like receptor signaling pathway | positive regulation of dendritic cell differentiation | organic substance catabolic process | lymphocyte differentiation | leukocyte degranulation | DNA catabolic process, endonucleolytic | regulation of cell motility | localization | cellular homeostasis | chromatin organization | protein transport | tissue remodeling | apoptotic nuclear changes | neuron development | apoptotic DNA fragmentation | T-helper 1 type immune response | immune system development | negative regulation of nucleic acid-templated transcription | negative regulation of alpha-beta T cell differentiation | macromolecule localization | regulation of chemotaxis | regulation of proteolysis | regulation of monocyte chemotaxis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of cellular metabolic process | regulation of binding | positive regulation of mismatch repair | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | DNA geometric change | negative regulation of cell motility | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | catabolic process | positive regulation of activated T cell proliferation | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | positive regulation of DNA ligation | T cell differentiation involved in immune response | regulation of endodeoxyribonuclease activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | calcium ion homeostasis | positive regulation of epithelial cell migration | T cell activation | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of vascular endothelial cell proliferation | negative regulation of apoptotic cell clearance | neutrophil degranulation | positive regulation of innate immune response | alpha-beta T cell activation involved in immune response | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | response to stress | negative regulation of lymphocyte activation | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of cell proliferation | negative regulation of interferon-gamma production | positive regulation of cell-cell adhesion | positive regulation of cysteine-type endopeptidase activity | execution phase of apoptosis | tumor necrosis factor production | inflammatory response to antigenic stimulus | programmed cell death | positive regulation of cell activation | activation of innate immune response | secretion by cell | cellular component disassembly involved in execution phase of apoptosis | positive regulation of cytokine secretion | positive regulation of proteolysis | negative regulation of DNA-templated transcription, initiation | cellular nitrogen compound metabolic process | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of transport | regulation of DNA binding | nucleic acid phosphodiester bond hydrolysis | positive regulation of blood vessel endothelial cell migration | apoptotic cell clearance | regulation of phagocytosis | regulation of protein transport | myeloid dendritic cell activation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | dendritic cell migration | hemopoiesis | negative regulation of hemopoiesis | regulation of peptide transport | regulation of cell adhesion | DNA recombination | nucleobase-containing compound catabolic process | cell chemotaxis | molecular function regulator | positive chemotaxis | metal ion homeostasis | regulation of lymphocyte differentiation | myeloid cell homeostasis | DNA repair | leukocyte migration | regulation of nucleic acid-templated transcription | T-helper cell differentiation | positive regulation of peptide secretion | leukocyte differentiation | regulation of cellular response to stress | locomotion | apoptotic process | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of monocyte chemotaxis | pattern recognition receptor signaling pathway | multicellular organism development | cell migration | regulation of toll-like receptor signaling pathway | regulation of peptidase activity | regulation of MAPK cascade | cellular response to DNA damage stimulus | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | T-helper 1 cell differentiation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | regulation of restriction endodeoxyribonuclease activity | regulation of activated T cell proliferation | regulation of gene expression | positive regulation of chemotaxis | positive regulation of secretion | organic substance transport | cellular response to stress | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | regulation of tolerance induction | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | regulation of cell migration | positive regulation of JNK cascade | regulation of cysteine-type endopeptidase activity involved in apoptotic process | dendritic cell chemotaxis | positive regulation of interleukin-12 production | peptide transport | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | positive regulation of hydrolase activity | positive regulation of cell differentiation | regulation of endothelial cell migration | regulation of mismatch repair | homeostasis of number of cells | positive regulation of cell migration | V(D)J recombination | negative regulation of epithelial cell migration | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | T cell activation involved in immune response | regulation of RNA polymerase II transcriptional preinitiation complex assembly | regulated exocytosis | positive regulation of interleukin-1 secretion | positive regulation of endopeptidase activity | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of leukocyte migration | autophagy | DNA topological change | negative regulation of blood vessel endothelial cell migration | regulation of interleukin-1 production | negative regulation of cell-cell adhesion | peptide secretion | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | chromatin remodeling | positive regulation of interleukin-1 production | positive regulation of leukocyte chemotaxis | regulation of alpha-beta T cell differentiation | negative regulation of cell activation | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | aromatic compound catabolic process | neutrophil activation involved in immune response | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of locomotion | regulation of RNA metabolic process | DNA ligation involved in DNA repair | positive regulation of transport | negative regulation of T cell differentiation | regulation of apoptotic cell clearance | lymphocyte activation | positive regulation of molecular function | regulation of cytokine secretion | neuron differentiation | cytokine production | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | activation of immune response | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of innate immune response | regulation of hemopoiesis | DNA metabolic process | import into cell | positive regulation of mononuclear cell migration | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | negative regulation of endocytosis | cell projection organization | metabolic process | cytokine secretion | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | amide transport | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | positive regulation of cell death | T-helper 1 cell activation | receptor ligand activity | positive regulation of toll-like receptor 9 signaling pathway | positive regulation of interleukin-6 production | regulation of response to DNA damage stimulus | immune response | nucleobase-containing compound metabolic process | neuron projection development | negative regulation of protein complex assembly | cytokine activity | organic substance metabolic process | cell death | negative regulation of biosynthetic process | chemoattractant activity | negative regulation of gene expression | animal organ development | regulation of endothelial cell proliferation | regulation of cell activation | negative regulation of cellular component movement | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | alpha-beta T cell activation | ion homeostasis | regulation of phosphate metabolic process | positive regulation of binding | establishment of protein localization | positive regulation of cytokine production | regulation of T cell mediated immune response to tumor cell | regulation of JNK cascade | positive regulation of endothelial cell migration | cell activation | positive regulation of MAPK cascade | negative regulation of transcription initiation from RNA polymerase II promoter | positive regulation of protein transport | regulation of epithelial cell migration | regulation of stress-activated MAPK cascade | regulation of cell communication | positive regulation of interleukin-10 production | regulation of blood vessel endothelial cell migration | signaling | regulation of transcription, DNA-templated | cell development | positive regulation of DNA binding | regulation of endocytosis | regulation of T cell proliferation | DNA ligation | protein localization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of cytokine production | somatic cell DNA recombination | regulation of endopeptidase activity | regulation of DNA-templated transcription, initiation | regulation of developmental process | positive regulation of DNA metabolic process | DNA catabolic process | developmental process | organelle organization | regulation of toll-like receptor 9 signaling pathway | negative regulation of alpha-beta T cell activation | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | innate immune response | regulation of dendritic cell differentiation | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | DNA conformation change | neutrophil mediated immunity | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | neutrophil clearance | positive regulation of metabolic process | chromosome organization | regulation of interferon-gamma production | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of protein localization | regulation of cell death | protein secretion | positive regulation of cell motility | regulation of interleukin-6 production | chemotaxis | divalent inorganic cation homeostasis | negative regulation of locomotion | phagocytosis | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of toll-like receptor signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process | positive regulation of interleukin-6 secretion | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | endoplasmic reticulum-Golgi intermediate compartment | chromosome | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | nuclear lumen | plasma membrane protein complex | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | alphav-beta3 integrin-HMGB1 complex | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane | vesicle | endosome | extracellular region | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | cell surface | intracellular | membrane | vesicle lumen | condensed chromosome
