QuickView for igo (gene)

Gene Symbol:

IGLL1 Homo sapiens

Full name:

immunoglobulin lambda like polypeptide 1

Synonyms:

14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, CD179b antigen, Pre-B lymphocyte-specific protein-2, ig lambda-5, immunoglobulin omega polypeptide chain, immunoglobulin-related 14.1 protein, immunoglobulin-related protein 14.1, lambda5

Genomic Location:

Chr 22: 22245312-22252495

Description:

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a...

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The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Rattus norvegicus

External Links:

Entrez Gene

Cytogenetic Map:

22q11.23

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