QuickView for interleukin 6 receptor (gene)

Gene Symbol:

IL6R Homo sapiens

Full name:

interleukin 6 receptor

Synonyms:

CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, interleukin-6 receptor subunit alpha, CD126 antigen, IL-6 receptor subunit alpha, IL-6R 1, membrane glycoprotein 80

Genomic Location:

Chr 1: 152644293-152706812

Description:

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a rece...

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This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ALX4_01 ,  YTATTTTNR_MEF2_02 ,  CAGGTG_E12_Q6 ,  AATGTGA_MIR23A_MIR23B

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-499

miRNA binding sites
(Source: miRecords):

hsa-miR-21 Targeted Genes

Cytogenetic Map:

1q21.3

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