QuickView for lamin c (gene)

Gene Symbol:

Lmna Mus musculus

Full name:

lamin A

Synonyms:

Dhe, prelamin-A/C, lamin C, lamin-A/C

Genomic Location:

Chr 3: 88285071-88307229

Description:

This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and r...

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This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  PAX6_01 ,  TST1_01 ,  OCT1_04 ,  COUP_01 ,  AP1FJ_Q2 ,  AP1_Q2 ,  AP1_Q6 ,  AP1_Q4 ,  AP1_C ,  NKX61_01 ,  CCTNTMAGA_UNKNOWN ,  ZIC1_01 ,  ZIC3_01 ,  NKX3A_01 ,  POU3F2_02 ,  CDC5_01 ,  BACH2_01 ,  BACH1_01 ,  AP1_01 ,  CTTTAAR_UNKNOWN ,  MAZ_Q6 ,  TEF1_Q6 ,  TFIII_Q6 ,  TFIIA_Q6 ,  HP1SITEFACTOR_Q6 ,  POU1F1_Q6 ,  MYB_Q3 ,  NF1_Q6_01 ,  AP1_Q2_01 ,  AP1_Q6_01 ,  GCAAAAA_MIR129 ,  ACCAAAG_MIR9 ,  TGCCTTA_MIR124A ,  WTGAAAT_UNKNOWN ,  YCATTAA_UNKNOWN ,  TGANTCA_AP1_C ,  GGGAGGRR_MAZ_Q6 ,  YTATTTTNR_MEF2_02 ,  TGCCAAR_NF1_Q6 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

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