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QuickView for latanoprost (compound)


PubChem
Name: latanoprost
PubChem Compound ID: 10477939
Molecular formula: C26H40O5
Molecular weight: 432.593 g/mol
DrugBank
Identification
Name: latanoprost
Name (isomeric): DB00654
Drug Type: small molecule
Brand: Xalatan Fixed Flow Device, Xalatan
Brand name mixture: Xalacom(Latanoprost + Timolol Maleate)
Category: Antihypertensive Agents, Neuroprotective Agents
CAS number: 130209-82-4
Pharmacology
Indication: For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Pharmacology:
Latanoprost is an isopropyl ester prodrug which is inactive but which becomes active after hydrolysis to the acid from. Latanoprost opthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow ...
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Mechanism of Action:
Latanoprost is a prostaglandin F2a analogue. Specifically, Latanoprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow. Elevated IOP represents a ma...
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Absorption: Latanoprost is well absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form. Peak concentration is reached 2 hrs after topical administration.
Biotransformation: Primarily hepatic (none except hydrolysis in the eye). Latanoprost is an isopropyl ester prodrug. It is hydrolyzed by esterases in the cornea to latanoprost acid, which is biologically active. The portion of the latanoprost acid that reaches the systemic circulation is metabolized primarily by the liver to 1,2-dinor and 1,2,3,4-tetranor metabolites by fatty acid beta-oxidation.
Half Life: 17 minutes
Clearance: 7 mL/min/kg
Toxicity: Symptoms of overdose include bloodshot eyes and eye irritation.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
BimatoprostThe concomitant use of bimatoprost and latanoprost may result in increased intraocular pressure. Consider avoiding this combination of therapy. Monitor for paradoxical increases in intraocular pressure during concomitant use.

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Transporters