QuickView for malectin (gene)

Gene Symbol:

MLEC Homo sapiens

Full name:

malectin

Synonyms:

KIAA0152, malectin, oligosaccharyltransferase complex subunit (non-catalytic)

Genomic Location:

Chr 12: 119609332-119624050

Description:

This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved ...

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This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  HNF4ALPHA_Q6 ,  TTTGCAC_MIR19A_MIR19B ,  AP1_C ,  TGANTCA_AP1_C ,  TTTGCAG_MIR518A2 ,  GGGATGC_MIR3245P ,  GATA3_01 ,  TTTTGAG_MIR373 ,  YRTCANNRCGC_UNKNOWN ,  NFY_C ,  GTACTGT_MIR101 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TTF1_Q6 ,  COUP_01 ,  HNF4_DR1_Q3 ,  HNF4_01 ,  TITF1_Q3 ,  NFY_Q6_01 ,  P53_02 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  HNF4_Q6 ,  GTTTGTT_MIR495 ,  NFY_01 ,  MGGAAGTG_GABP_B ,  NFY_Q6 ,  GTGCCTT_MIR506 ,  CETS1P54_01 ,  SCGGAAGY_ELK1_02 ,  GTCNYYATGR_UNKNOWN ,  GAGCCAG_MIR149 ,  WTTGKCTG_UNKNOWN ,  NRF2_01 ,  CTGAGCC_MIR24 ,  TGCTTTG_MIR330 ,  CTCTAGA_MIR526C_MIR518F_MIR526A ,  AACTTT_UNKNOWN ,  GTTAAAG_MIR302B ,  HNF4_01_B ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-380-5p ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

12q24.31

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