QuickView for map kinase kinase 1 (gene)
- Gene Symbol:
- Map2k1
Mus musculus - Full name:
- mitogen-activated protein kinase kinase 1
- Synonyms:
- MAPKK1, MEKK1, Mek1, Prkmk1, dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK 1, protein kinase, mitogen activated, kinase 1, p45
- Genomic Location:
- Chr 9: 64033600-64101412
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
protein kinase activator activity | protein serine/threonine kinase activator activity | kinase binding | enzyme activator activity | protein kinase regulator activity | GTPase binding | kinase regulator activity | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | protein N-terminus binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | scaffold protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | mitogen-activated protein kinase kinase kinase binding | protein tyrosine kinase activity | protein binding | MAP kinase kinase activity | kinase activator activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | heterocyclic compound binding | protein C-terminus binding | small molecule binding
GO Biological Process
regulation of ERK1 and ERK2 cascade | brain development | regulation of blood vessel diameter | cell morphogenesis | regulation of muscle system process | protein kinase activator activity | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | protein serine/threonine kinase activator activity | microtubule-based transport | positive regulation of Ras protein signal transduction | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | developmental process involved in reproduction | regulation of cellular localization | positive regulation of ATP metabolic process | intracellular signal transduction | enzyme activator activity | regulation of cell development | regulation of localization | protein kinase regulator activity | regulation of programmed cell death | peptidyl-amino acid modification | establishment of localization | regulation of autophagy | response to hormone | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | respiratory tube development | nervous system development | regulation of smooth muscle contraction | cerebellum morphogenesis | cell part morphogenesis | positive regulation of axonogenesis | neurogenesis | glucose homeostasis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | vesicle cytoskeletal trafficking | intracellular transport | microtubule-based process | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | regulation of production of miRNAs involved in gene silencing by miRNA | establishment of organelle localization | regulation of cell motility | localization | cell projection morphogenesis | negative regulation of signaling | neuron development | kinase regulator activity | reproductive system development | immune system development | pigment granule transport | positive regulation of protein kinase activity | negative regulation of apoptotic process | endomembrane system organization | regulation of cell cycle | positive regulation of catalytic activity | lung epithelium development | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | establishment of localization in cell | tissue development | regulation of cell differentiation | cytoskeleton-dependent intracellular transport | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | organelle localization | positive regulation of cellular protein metabolic process | epithelium development | regulation of gene silencing by miRNA | cellular component organization | Golgi inheritance | MAPK cascade | head development | thyroid gland development | regulation of vascular smooth muscle contraction | response to stimulus | peptidyl-threonine phosphorylation | thymus development | vasculature development | respiratory system development | metencephalon development | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | regulation of blood vessel size | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | response to stress | organelle transport along microtubule | regulation of cell proliferation | regulation of blood circulation | protein serine/threonine kinase activity | microtubule-based movement | reproduction | cellular localization | cardiovascular system development | regulation of gene silencing | regulation of neuron projection regeneration | blood circulation | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | melanosome localization | regulation of cell adhesion | embryo development | macromolecule modification | trachea morphogenesis | activation of protein kinase activity | positive regulation of production of miRNAs involved in gene silencing by miRNA | regulation of intracellular transport | molecular function regulator | embryonic placenta development | blood vessel development | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of cellular response to hypoxia | positive regulation of neuron projection development | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | regulation of axonogenesis | protein complex oligomerization | regulation of muscle contraction | regulation of catalytic activity | cerebellum development | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | response to lipid | cell cycle | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | response to axon injury | animal organ morphogenesis | positive regulation of ATP biosynthetic process | regulation of nitrogen compound metabolic process | placenta blood vessel development | regulation of cell migration | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to oxidative stress | pigmentation | epithelial cell proliferation involved in lung morphogenesis | positive regulation of hydrolase activity | positive regulation of cell differentiation | epidermal cell differentiation | positive regulation of cell migration | establishment of vesicle localization | cell proliferation | labyrinthine layer development | regulation of cellular protein metabolic process | glial cell differentiation | hindbrain development | regulation of transcription elongation from RNA polymerase II promoter | phosphorylation | triglyceride homeostasis | epidermis development | regulation of GTPase activity | regulation of apoptotic signaling pathway | skin development | endocrine system development | protein phosphorylation | keratinocyte differentiation | phosphate-containing compound metabolic process | trachea formation | negative regulation of cell-cell adhesion | chordate embryonic development | animal organ formation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | astrocyte differentiation | cerebellar cortex morphogenesis | regulation of protein metabolic process | positive regulation of signal transduction | heart development | homeostatic process | regulation of Golgi inheritance | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of tube size | establishment of melanosome localization | cell aging | negative regulation of homotypic cell-cell adhesion | protein tyrosine kinase activity | positive regulation of molecular function | neuron differentiation | activation of MAPK activity | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of protein modification process | response to organic substance | gland development | regulation of homotypic cell-cell adhesion | cell cycle arrest | Golgi organization | epithelial cell proliferation | regulation of kinase activity | response to wounding | MAP kinase kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | kinase activator activity | mitotic cell cycle | positive regulation of neurogenesis | positive regulation of small GTPase mediated signal transduction | regulation of vasoconstriction | cell projection organization | metabolic process | positive regulation of cell development | positive regulation of transcription elongation from RNA polymerase II promoter | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | transport along microtubule | regulation of tube diameter | cerebellar cortex development | regulation of vesicle-mediated transport | hindbrain morphogenesis | chemical homeostasis | trachea development | regulation of gene silencing by RNA | protein kinase activity | neuron projection development | positive regulation of muscle contraction | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of gene expression | animal organ development | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of ATP metabolic process | regulation of phosphate metabolic process | Bergmann glial cell differentiation | positive regulation of autophagy | regulation of DNA-templated transcription, elongation | positive regulation of MAPK cascade | lung development | regulation of axon regeneration | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | cerebellar cortex formation | regulation of response to wounding | regulation of stress-activated MAPK cascade | regulation of cell communication | cellular senescence | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | regulation of production of small RNA involved in gene silencing by RNA | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of Ras protein signal transduction | protein heterooligomerization | anatomical structure morphogenesis | positive regulation of MAP kinase activity | protein serine/threonine/tyrosine kinase activity | reproductive structure development | regulation of nervous system development | positive regulation of gene silencing by miRNA | regulation of developmental process | kinase activity | organelle inheritance | developmental process | positive regulation of DNA-templated transcription, elongation | organelle organization | cellular pigmentation | cellular protein modification process | vesicle transport along microtubule | acylglycerol homeostasis | tube development | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | lung morphogenesis | epithelial cell differentiation | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | central nervous system development | in utero embryonic development | positive regulation of metabolic process | vesicle localization | positive regulation of neuron differentiation | regulation of cell projection organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | pigment granule localization | placenta development | regulation of cell death | positive regulation of cell motility | response to steroid hormone | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | circulatory system development | aging | carbohydrate homeostasis | regulation of early endosome to late endosome transport | lipid homeostasis | regulation of cellular component organization | regulation of Golgi organization | positive regulation of signaling | negative regulation of cellular response to hypoxia | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | macromolecule metabolic process | multicellular organismal process | face development | melanosome transport | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | dendrite | intracellular membrane-bounded organelle | late endosome | neuron projection | somatodendritic compartment | adherens junction | focal adhesion | cytoplasmic vesicle | cell body | cell | neuronal cell body | microtubule | cytoplasm | dendrite cytoplasm | cell-substrate junction | intracellular organelle | endoplasmic reticulum | dendritic tree | Golgi apparatus | cell projection | endomembrane system | plasma membrane bounded cell projection cytoplasm | plasma membrane | perikaryon | vesicle | perinuclear region of cytoplasm | microtubule cytoskeleton | cytoplasmic region | mitochondrion | endosome | cell cortex | membrane-bounded organelle | nucleus | organelle | cell periphery | axon | early endosome | cell-substrate adherens junction | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex
