QuickView for matrix metalloproteinase 14 (gene)

Gene Symbol:

MMP14 Homo sapiens

Full name:

matrix metallopeptidase 14

Synonyms:

MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS, matrix metalloproteinase-14, matrix metallopeptidase 14 (membrane-inserted), membrane type 1 metalloprotease, membrane-type-1 matrix metalloproteinase

Genomic Location:

Chr 14: 22375633-22386643

Description:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when...

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SMTTTTGT_UNKNOWN ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  VDR_Q3 ,  HOXA4_Q2 ,  YTATTTTNR_MEF2_02 ,  XBP1_01 ,  SREBP1_Q6 ,  GR_Q6_01 ,  AP2ALPHA_01 ,  AML1_01 ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  TTGGGAG_MIR150 ,  CAGGTA_AREB6_01 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  NCX_01 ,  AML1_Q6 ,  EN1_01 ,  HAND1E47_01 ,  CTGAGCC_MIR24 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  RORA2_01 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  PAX4_03 ,  TATTATA_MIR374

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

14q11.2

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