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Name: Menthol
PubChem Compound ID: 1254
Description: An alcohol produced from mint oils or prepared synthetically.
Molecular formula: C10H20O
Molecular weight: 156.265 g/mol
Peppermint camphor; Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.beta.,5.alpha.)-; EINECS 216-074-4; Menthol racemic; 15356-70-4; CCRIS 375; Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1.alpha.,2.alpha.,5.beta.)]-; (+-)-(1R*,3R*,4S*)-Menthol; BRN 3194263; Hexahydrothymol.
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Name: Menthol
Name (isomeric): DB00825
Drug Type: small molecule
Description: An alcohol produced from mint oils or prepared synthetically.
Levomenthol; (r)-(-)-menthol; L-(-)-menthol; (-)-menthol; L-menthol
Brand name mixture:
Vicks vaporub lotion(camphor + eucalyptus oil + menthol), Gold bond medicated lotion(regular strength) (dimethicone + menthol), Gouttes dentaires(benzocaine + camphor + clove oil + guaiacol + menthol), Herbon lemon honey flavour herbal throat drops(echinacea (echinacea angustifolia, echinacea purpurea) + menthol), Strepsils cherry(amylmetacresol...
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Category: Antipruritics
CAS number: 2216-51-5
Indication: Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants.
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthol's ability to chemically trigger cold-sensitive receptors in the skin is responsible for the well known cooling sensation that it provokes when inhalated, eaten, or applied to the skin. It should be noted that menthol does not cause an a...
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Mechanism of Action: Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
Toxicity: Menthol, DL: ORAL (LD50): Acute: 2900 mg/kg [Rat], 3100 mg/kg [Mouse]. DERMAL (LD50): Acute: 5001 mg/kg [Rabbit].
Affected organisms: Humans and other mammals