QuickView for mmp20 (gene)

Gene Symbol:

MMP20 Homo sapiens

Full name:

matrix metallopeptidase 20

Synonyms:

AI2A2, MMP-20, matrix metalloproteinase-20, enamel metalloproteinase, matrix metalloproteinase 20 (enamelysin)

Genomic Location:

Chr 11: 101952776-102001273

Description:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when...

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TFIIA_Q6 ,  TGANTCA_AP1_C ,  TATAAA_TATA_01 ,  TATA_C ,  TAATTA_CHX10_01 ,  TATA_01

Cytogenetic Map:

11q22.2

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