QuickView for nanH (gene)

Gene Symbol:

NEU1 Homo sapiens

Full name:

neuraminidase 1

Synonyms:

NANH, NEU, SIAL1, sialidase-1, G9 sialidase, N-acetyl-alpha-neuraminidase 1, acetylneuraminyl hydrolase, exo-alpha-sialidase, lysosomal sialidase, sialidase 1 (lysosomal sialidase)

Genomic Location:

Chr 6: 31934931-31938662

Description:

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene ca...

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The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTCAGGG_MIR125B_MIR125A

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125

Cytogenetic Map:

6p21.33

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