QuickView for neuropilin-1 (gene)

Gene Symbol:

NRP1 Homo sapiens

Full name:

neuropilin 1

Synonyms:

BDCA4, CD304, NP1, NRP, VEGF165R, neuropilin-1, transmembrane receptor, vascular endothelial cell growth factor 165 receptor

Genomic Location:

Chr 10: 33506432-33663839

Description:

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also ...

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This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  HNF1_01 ,  CCCAGAG_MIR326 ,  RYTTCCTG_ETS2_B ,  HOXA4_Q2 ,  AP3_Q6 ,  POU3F2_01 ,  FOXD3_01 ,  HFH1_01 ,  PEA3_Q6 ,  IPF1_Q4 ,  LYF1_01 ,  CAGTGTT_MIR141_MIR200A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  MEIS1BHOXA9_01 ,  ACTTTAT_MIR1425P ,  TTGCACT_MIR130A_MIR301_MIR130B ,  HNF1_C ,  TTTNNANAGCYR_UNKNOWN ,  COUP_01 ,  AAGCAAT_MIR137 ,  TGACCTY_ERR1_Q2 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  EVI1_03 ,  ACATTCC_MIR1_MIR206 ,  ATGCTGG_MIR338 ,  CDX2_Q5 ,  STAT5B_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  ETS2_B ,  CAGCTTT_MIR320 ,  PXR_Q2 ,  LHX3_01 ,  EVI1_02 ,  EVI1_05 ,  AREB6_01 ,  TGCTGAY_UNKNOWN ,  OCT1_03 ,  NERF_Q2 ,  S8_01 ,  IRF_Q6 ,  POU1F1_Q6 ,  MEIS1_01 ,  SOX5_01 ,  YCATTAA_UNKNOWN ,  RORA1_01 ,  STAT_01 ,  GTGCCTT_MIR506 ,  MEIS1AHOXA9_01 ,  TCTATGA_MIR376A_MIR376B ,  TAATTA_CHX10_01 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  PIT1_Q6 ,  GATA4_Q3 ,  WTTGKCTG_UNKNOWN ,  IRF7_01 ,  TEF_Q6 ,  RGAGGAARY_PU1_Q6 ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  SMAD_Q6 ,  CDC5_01 ,  SRY_02 ,  GGCAGTG_MIR3243P ,  GTTAAAG_MIR302B ,  HNF1_Q6 ,  ELF1_Q6 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137

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Cytogenetic Map:

10p11.22

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