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QuickView for nucleolin (gene)


Gene Symbol:
NCL Homo sapiens Homo sapiens
Full name:
nucleolin
Synonyms:
C23, Nsr1, nucleolin
Genomic Location:
Chr 2: 232027703-232037449
Description:
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q37.1





GO Molecular Function

sequence-specific DNA binding | enzyme binding | nucleic acid binding | mRNA binding | DNA topoisomerase binding | DNA binding | identical protein binding | organic cyclic compound binding | protein binding | mRNA 5'-UTR binding | heterocyclic compound binding | telomeric DNA binding | protein C-terminus binding | RNA binding

GO Biological Process

positive regulation of macromolecule biosynthetic process | response to cytokine | regulation of transcription by RNA polymerase I | negative regulation of cellular process | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | response to stimulus | vasculature development | posttranscriptional regulation of gene expression | tube morphogenesis | cardiovascular system development | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | blood vessel development | regulation of nucleic acid-templated transcription | system development | multicellular organism development | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | angiogenesis | regulation of cellular metabolic process | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I | regulation of protein metabolic process | regulation of RNA metabolic process | cellular response to epidermal growth factor stimulus | response to organic substance | anatomical structure development | regulation of RNA biosynthetic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | positive regulation of transcription by RNA polymerase I | negative regulation of translation | response to epidermal growth factor | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | cellular response to leukemia inhibitory factor | regulation of transcription, DNA-templated | anatomical structure morphogenesis | developmental process | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | cellular response to organic substance | regulation of translation | circulatory system development | positive regulation of gene expression | cellular response to growth factor stimulus | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | ribonucleoprotein granule | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | ribonucleoprotein complex | vesicle | extracellular exosome | cytoplasmic region | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | extracellular space | cell periphery | membrane-enclosed lumen | intracellular | membrane