The major royal jelly proteins (MRJPs) comprise 12.5% of the mass, and 82-90% of the protein content, of honeybee (Apis mellifera) royal jelly. Royal jelly is a substance secreted by the cephalic glands of nurse bees and it is used to trigger development of a queen bee from a bee larva. The biological function of the MRJPs is unknown, but they are believed to play a major role in nutrition due to their high essential amino acid content. Two royal jelly proteins, MRJP3 and MRJP5, contain a tandem repeat that results from a high genetic variablility. This polymorphism may be useful for genotyping individual bees.This family also includes related proteins such as protein yellow-f and yellow-f2 from Drosphila, which are dopachrome-conversion enzymes responsible for catalysing the conversion of dopachrome into 5,6-dihydroxyindole in the melanization pathway. This family of yellow-like proteins has only been identified within insects and a number of bacterial species.