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QuickView for opa1 (gene)


Gene Symbol:
OPA1 Homo sapiens Homo sapiens
Full name:
OPA1, mitochondrial dynamin like GTPase
Synonyms:
BERHS, MGM1, MTDPS14, NPG, NTG, largeG, dynamin-like 120 kDa protein, mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, optic atrophy 1 (autosomal dominant), optic atrophy protein 1
Genomic Location:
Chr 3: 194793806-194898009
Description:
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atro...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 3
3q29





GO Molecular Function

kinase binding | guanyl ribonucleotide binding | ribonucleoside binding | cation binding | magnesium ion binding | enzyme binding | ribonucleotide binding | lipid binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | phospholipid binding | pyrophosphatase activity | catalytic activity | phosphatidylglycerol binding | cytoskeletal protein binding | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | microtubule binding | nucleoside binding | purine ribonucleotide binding | tubulin binding | cardiolipin binding | metal ion binding | heterocyclic compound binding | phosphatidic acid binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

response to extracellular stimulus | purine ribonucleotide metabolic process | inner mitochondrial membrane organization | cellular response to decreased oxygen levels | response to nutrient levels | microtubule-based transport | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cell development | cytosolic calcium ion transport | regulation of localization | organelle fusion | regulation of programmed cell death | eye development | establishment of localization | negative regulation of cellular process | membrane fusion | positive regulation of developmental process | cell differentiation | nervous system development | cellular response to extracellular stimulus | negative regulation of mitochondrion organization | response to drug | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | glucose homeostasis | regulation of organelle organization | generation of neurons | membrane organization | response to antibiotic | intracellular transport | microtubule-based process | positive regulation of dendritic spine morphogenesis | calcium ion import | cellular process | establishment of organelle localization | regulation of glucose import | regulation of dendritic spine morphogenesis | localization | cellular homeostasis | positive regulation of neuron maturation | mitochondrial fusion | nucleotide metabolic process | negative regulation of signaling | metal ion transport | ribose phosphate metabolic process | negative regulation of response to endoplasmic reticulum stress | mitochondrial calcium ion transmembrane transport | negative regulation of apoptotic process | response to hypoxia | nucleoside triphosphate metabolic process | negative regulation of release of cytochrome c from mitochondria | ribonucleotide metabolic process | regulation of neuron projection development | establishment of localization in cell | regulation of cell differentiation | cytoskeleton-dependent intracellular transport | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | organelle localization | response to ether | organic cyclic compound metabolic process | regulation of cell maturation | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | regulation of mitochondrial fusion | positive regulation of dendrite morphogenesis | mitochondrion morphogenesis | response to stimulus | purine nucleotide metabolic process | cellular response to hypoxia | response to stress | organelle transport along microtubule | regulation of response to endoplasmic reticulum stress | positive regulation of glucose import | response to glucose | programmed cell death | response to L-glutamate | microtubule-based movement | cellular localization | divalent metal ion transport | cellular nitrogen compound metabolic process | cellular component assembly | regulation of synapse structure or activity | purine nucleoside metabolic process | mitochondrion organization | mitochondrion transport along microtubule | positive regulation of mitochondrion organization | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | positive regulation of neuron projection development | multicellular organism development | response to activity | cellular glucose homeostasis | calcium ion transmembrane transport | phosphorus metabolic process | regulation of neuron maturation | response to amino acid | protein complex oligomerization | regulation of intrinsic apoptotic signaling pathway | ion transmembrane transport | positive regulation of glucose import in response to insulin stimulus | regulation of neuron differentiation | response to ketone | cellular response to stress | nervous system process | regulation of glucose import in response to insulin stimulus | organophosphate metabolic process | nucleoside metabolic process | membrane fission | mitochondrial transport | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | cellular response to oxygen levels | regulation of synapse organization | small molecule metabolic process | positive regulation of cell projection organization | protein polymerization | response to nutrient | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | mitochondrion localization | positive regulation of glucose transmembrane transport | positive regulation of cell maturation | cellular protein-containing complex assembly | regulation of apoptotic signaling pathway | positive regulation of dendritic spine development | cellular response to amino acid stimulus | phosphate-containing compound metabolic process | sensory organ development | positive regulation of cellular response to insulin stimulus | cellular response to drug | regulation of mitochondrion organization | mitochondrial membrane organization | response to curcumin | cell communication | mitochondrial genome maintenance | GTP metabolic process | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | inner ear development | homeostatic process | response to monosaccharide | positive regulation of transport | cell aging | positive regulation of dendrite development | cation transmembrane transport | mitochondrion distribution | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | cellular response to nutrient | response to organic substance | retina development in camera-type eye | establishment of mitochondrion localization, microtubule-mediated | response to antineoplastic agent | establishment of mitochondrion localization | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of dendrite morphogenesis | positive regulation of neurogenesis | calcium import into the mitochondrion | metabolic process | positive regulation of cell development | visual perception | negative regulation of programmed cell death | transport along microtubule | ear development | cellular response to carbohydrate stimulus | chemical homeostasis | calcium ion transport | mitochondrial transmembrane transport | dynamin family protein polymerization involved in mitochondrial fission | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | cell death | regulation of glucose transmembrane transport | animal organ development | sensory perception of light stimulus | intracellular distribution of mitochondria | regulation of cellular response to insulin stimulus | inorganic cation transmembrane transport | regulation of postsynapse organization | camera-type eye development | regulation of dendrite development | sensory perception | regulation of cell communication | axo-dendritic transport | cellular senescence | negative regulation of signal transduction | transmembrane transport | regulation of dendritic spine development | response to organic cyclic compound | anatomical structure morphogenesis | cation transport | regulation of nervous system development | regulation of developmental process | developmental process | axonal transport of mitochondrion | organelle organization | carbohydrate derivative metabolic process | regulation of transport | membrane tubulation | cochlea development | response to organonitrogen compound | heterocycle metabolic process | response to electrical stimulus | positive regulation of neuron differentiation | mitochondrial fission | ion transport | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of cell death | response to carbohydrate | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | positive regulation of mitochondrial fusion | aging | carbohydrate homeostasis | cellular response to L-glutamate | regulation of cellular component organization | axonal transport | regulation of signaling | response to muscle activity | multicellular organismal process

GO Cellular Component

integral component of membrane | mitochondrial intermembrane space | organelle inner membrane | dendrite | intracellular membrane-bounded organelle | mitochondrial inner membrane | extrinsic component of organelle membrane | neuron projection | extrinsic component of mitochondrial inner membrane | extrinsic component of membrane | somatodendritic compartment | organelle membrane | cell | organelle outer membrane | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | dendritic tree | mitochondrial crista | cell projection | nucleoplasm | plasma membrane bounded cell projection cytoplasm | cytoplasmic region | mitochondrion | membrane-bounded organelle | nucleus | organelle | axon cytoplasm | mitochondrial outer membrane | mitochondrial envelope | axon | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular | membrane