QuickView for pacrg (gene)

Gene Symbol:

PACRG Homo sapiens

Full name:

parkin coregulated

Synonyms:

GLUP, HAK005771, PARK2CRG, parkin coregulated gene protein, PARK2 co-regulated, PARK2 coregulated, molecular chaperone/chaperonin-binding protein, parkin co-regulated gene protein

Genomic Location:

Chr 6: 163068154-163656514

Description:

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associate...

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This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTCCCRNNAGGY_UNKNOWN ,  MIF1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  GTACTGT_MIR101 ,  CYTAGCAAY_UNKNOWN ,  RFX1_01 ,  TAL1BETAE47_01 ,  CAGGTA_AREB6_01 ,  RP58_01 ,  TGCGCANK_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  NRF1_Q6 ,  YGCGYRCGC_UNKNOWN ,  AAAYRNCTG_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  RCGCANGCGY_NRF1_Q6 ,  PAX2_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-381

Cytogenetic Map:

6q26

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