QuickView for past (gene)

Gene Symbol:

EHD1 Homo sapiens

Full name:

EH domain containing 1

Synonyms:

H-PAST, HPAST1, PAST, PAST1, EH domain-containing protein 1, PAST homolog 1, testilin

Genomic Location:

Chr 11: 64376784-64402767

Description:

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sor...

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This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  IRF1_01 ,  ATAAGCT_MIR21 ,  SMTTTTGT_UNKNOWN ,  RSRFC4_01 ,  GCANCTGNY_MYOD_Q6 ,  TACTTGA_MIR26A_MIR26B ,  IRF1_Q6 ,  WTGAAAT_UNKNOWN ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  TEF1_Q6 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  ATF3_Q6 ,  IRF_Q6 ,  HMEF2_Q6 ,  AREB6_03 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  ATF1_Q6 ,  CREL_01 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  RCGCANGCGY_NRF1_Q6 ,  MMEF2_Q6 ,  AAACCAC_MIR140 ,  TGACATY_UNKNOWN ,  HNF4_01_B ,  FOXO4_02 ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-155

Cytogenetic Map:

11q13.1

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