QuickView for pcgf1 (gene)
- Gene Symbol:
- PCGF1
Homo sapiens - Full name:
- polycomb group ring finger 1
- Synonyms:
- 2010002K04Rik, NSPC1, RNF3A-2, RNF68, polycomb group RING finger protein 1, RING finger protein 68, nervous system Polycomb-1
- Genomic Location:
- Chr 2: 74585678-74588329
- Description:
-
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
2p13.1
GO Molecular Function
cation binding | chromatin binding | promoter-specific chromatin binding | ion binding | protein binding | metal ion binding | protein C-terminus binding
GO Biological Process
RNA metabolic process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | histone H2A ubiquitination | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | histone H2A-K119 monoubiquitination | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | protein monoubiquitination | histone H2A monoubiquitination | regulation of gene expression | negative regulation of gene expression, epigenetic | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | protein metabolic process | protein ubiquitination | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | protein modification by small protein conjugation or removal | transcription, DNA-templated | histone ubiquitination | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | organelle organization | cellular protein modification process | histone monoubiquitination | negative regulation of transcription by RNA polymerase II | heterocycle metabolic process | chromosome organization | chromatin silencing | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
PRC1 complex | PcG protein complex | intracellular membrane-bounded organelle | catalytic complex | nuclear ubiquitin ligase complex | cell | nuclear lumen | intracellular organelle | ubiquitin ligase complex | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
