QuickView for pcna (gene)
- Gene Symbol:
- PCNA
Homo sapiens - Full name:
- proliferating cell nuclear antigen
- Synonyms:
- ATLD2, proliferating cell nuclear antigen, DNA polymerase delta auxiliary protein, cyclin
- Genomic Location:
- Chr 20: 5043599-5055268
- Description:
-
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two tr...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
ATGCAGT_MIR217 , E2F1_Q4_01 , E2F4DP1_01 , E2F_Q6_01 , E2F_01 , E2F1_Q4 , E2F_Q6 , ALPHACP1_01 , E2F1_Q6_01 , E2F_Q4
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
20p12.3
GO Molecular Function
DNA N-glycosylase activity | kinase binding | dinucleotide insertion or deletion binding | hormone receptor binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | DNA polymerase binding | estrogen receptor binding | signaling receptor binding | hydrolase activity | mismatched DNA binding | hydrolase activity, hydrolyzing N-glycosyl compounds | MutLalpha complex binding | molecular function regulator | catalytic activity | chromatin binding | DNA insertion or deletion binding | DNA polymerase processivity factor activity | DNA binding | identical protein binding | nuclear hormone receptor binding | damaged DNA binding | hydrolase activity, acting on glycosyl bonds | purine-specific mismatch base pair DNA N-glycosylase activity | organic cyclic compound binding | protein tyrosine kinase binding | protein binding | histone acetyltransferase binding | double-stranded DNA binding | transcription factor binding | enzyme regulator activity | steroid hormone receptor binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | response to extracellular stimulus | response to radiation | error-free translesion synthesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | response to nutrient levels | detection of stimulus | intracellular signal transduction | regulation of cell cycle G1/S phase transition | translesion synthesis | response to hormone | negative regulation of cellular process | response to dexamethasone | response to metal ion | cell differentiation | response to drug | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of DNA replication | response to antibiotic | regulation of DNA repair | positive regulation of cellular biosynthetic process | cellular process | DNA-dependent DNA replication maintenance of fidelity | cellular homeostasis | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | response to estradiol | cell cycle DNA replication | multicellular organismal reproductive process | postreplication repair | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | tissue development | anatomical structure homeostasis | regeneration | response to hydrogen peroxide | regulation of cellular process | regulation of metabolic process | hepaticobiliary system development | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | DNA-dependent DNA replication | cellular component organization | positive regulation of response to DNA damage stimulus | response to UV | response to stimulus | regulation of mitotic cell cycle phase transition | cellular response to light stimulus | response to stress | cellular nitrogen compound biosynthetic process | ovulation cycle | regulation of cell cycle phase transition | response to L-glutamate | reproduction | rhythmic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | telomere organization | positive regulation of nuclease activity | cell cycle G1/S phase transition | nucleic acid phosphodiester bond hydrolysis | protein modification process | cellular biosynthetic process | macromolecule modification | molecular function regulator | positive regulation of deoxyribonuclease activity | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | replication fork processing | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | positive regulation of DNA replication | response to amino acid | cellular response to DNA damage stimulus | regulation of catalytic activity | cellular response to oxidative stress | nucleotide-excision repair, DNA incision, 5'-to lesion | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | DNA biosynthetic process | response to ketone | cellular response to stress | response to lipid | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | DNA polymerase processivity factor activity | cellular response to radiation | error-prone translesion synthesis | liver development | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | response to corticosteroid | response to nutrient | response to oxidative stress | positive regulation of hydrolase activity | telomere maintenance via semi-conservative replication | cell proliferation | biosynthetic process | response to cadmium ion | aromatic compound biosynthetic process | response to toxic substance | mismatch repair | signal transduction involved in cell cycle checkpoint | response to xenobiotic stimulus | mitotic cell cycle phase transition | cellular response to UV | cellular response to drug | DNA strand elongation | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | liver regeneration | regulation of transcription involved in G1/S transition of mitotic cell cycle | heart development | homeostatic process | G1/S transition of mitotic cell cycle | regulation of RNA metabolic process | nucleotide-excision repair, DNA gap filling | regulation of mitotic cell cycle | positive regulation of molecular function | positive regulation of cell cycle arrest | multicellular organism reproduction | protein metabolic process | response to organic substance | gland development | protein ubiquitination | G1 DNA damage checkpoint | DNA metabolic process | response to antineoplastic agent | nucleotide-excision repair, DNA incision | anatomical structure development | mitotic cell cycle | DNA damage response, detection of DNA damage | metabolic process | nucleotide-excision repair | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | cellular response to hydrogen peroxide | leading strand elongation | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | animal organ development | response to reactive oxygen species | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | negative regulation of cell cycle | estrous cycle | transcription-coupled nucleotide-excision repair | negative regulation of cell cycle G1/S phase transition | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular protein metabolic process | enzyme regulator activity | cellular macromolecule biosynthetic process | signal transduction involved in DNA damage checkpoint | mitotic telomere maintenance via semi-conservative replication | nuclear DNA replication | positive regulation of DNA metabolic process | developmental process | organelle organization | positive regulation of cell cycle process | cellular protein modification process | mitotic G1/S transition checkpoint | DNA synthesis involved in DNA repair | DNA strand elongation involved in DNA replication | response to organonitrogen compound | cell cycle phase transition | epithelial cell differentiation | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | response to steroid hormone | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | circulatory system development | signal transduction | animal organ regeneration | response to glucocorticoid | positive regulation of DNA repair | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | nuclear replication fork | microtubule organizing center | cell | nuclear lumen | replication fork | intracellular organelle | DNA replication factor C complex | nuclear body | centrosome | protein-containing complex | protein-DNA complex | nucleoplasm | nuclear chromosome | vesicle | extracellular exosome | microtubule cytoskeleton | chromosome, telomeric region | PCNA complex | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | PCNA-p21 complex | replisome | extracellular space | membrane-enclosed lumen | cytoskeleton | nuclear chromosome, telomeric region | intracellular
