QuickView for protoporphyria (gene)

Gene Symbol:

FECH Homo sapiens

Full name:

ferrochelatase

Synonyms:

EPP, FCE, ferrochelatase, mitochondrial, heme synthase, heme synthetase, protoheme ferro-lyase, protoporphyria

Genomic Location:

Chr 18: 53366535-53404988

Description:

The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudoge...

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The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGT_LEF1_Q2

Cytogenetic Map:

18q21.31

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