QuickView for retinoblastoma binding protein 2 (gene)

Gene Symbol:

KDM5A Homo sapiens

Full name:

lysine demethylase 5A

Synonyms:

RBBP-2, RBBP2, RBP2, lysine-specific demethylase 5A, Jumonji, AT rich interactive domain 1A (RBP2-like), histone demethylase JARID1A, jumonji/ARID domain-containing protein 1A, lysine (K)-specific demethylase 5A, retinoblastoma binding protein 2

Genomic Location:

Chr 12: 259484-368881

Description:

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is impli...

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This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATCMNTCCGY_UNKNOWN ,  TEF1_Q6 ,  CAGCTTT_MIR320 ,  GCAAGAC_MIR431 ,  SOX5_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  SCGGAAGY_ELK1_02 ,  ERR1_Q2 ,  SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-431 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

12p13.33

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