Bookmark
Forward
QuickView for rhTSH (compound)
DrugBank
Identification
| Name: | Thyrotropin Alfa |
|---|---|
| Name (isomeric): | DB00024 |
| Drug Type: | biotech |
| Description: | A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. |
| Synonyms: |
FSH-B; Follitropin beta chain precursor; Follicle-stimulating hormone beta subunit; FSH-beta
|
| Brand: | Thyrogen (Genzyme Inc) |
| Category: | Diagnostic Agents |
| CAS number: | 9002-71-5 |
Pharmacology
| Indication: | For detection of residueal or recurrent thyroid cancer |
|---|---|
| Pharmacology: | Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. Thyrogen is an exogenous source of human TSH that offers an additional diagnostic tool in the follow-up of patients with a history of well-differentiated thyroid cancer. |
| Mechanism of Action: | Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging. |
| Half Life: | 5 +/- 10 hrs |
| Affected organisms: | Humans and other mammals |
Targets
