QuickView for rho-kinase (gene)
- Gene Symbol:
- Rock2
Mus musculus - Full name:
- Rho-associated coiled-coil containing protein kinase 2
- Synonyms:
- B230113H15Rik, ROKalpha, Rho-kinase, Rock-II, Rock2m, mKIAA0619, rho-associated protein kinase 2, Rho-associated coiled-coil forming kinage 2, p164 ROCK-2, rho-associated, coiled-coil-containing protein kinase 2, rho-associated, coiled-coil-containing protein kinase II
- Genomic Location:
- Chr 12: 16901784-16995080
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
GTPase binding | Rho GTPase binding | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | Rho-dependent protein serine/threonine kinase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of supramolecular fiber organization | cell morphogenesis | regulation of muscle system process | regulation of cell cycle process | positive regulation of amyloid precursor protein catabolic process | positive regulation of locomotion | regulation of dephosphorylation | actin filament-based process | positive regulation of cellular component organization | positive regulation of protein localization to early endosome | neuron projection morphogenesis | protein localization to cell periphery | regulation of cellular localization | intracellular signal transduction | negative regulation of protein localization to lysosome | regulation of cell development | regulation of localization | morphogenesis of an epithelium | peptidyl-amino acid modification | actin cytoskeleton organization | response to hormone | negative regulation of cellular process | regulation of phosphatase activity | microtubule cytoskeleton organization | cell differentiation | nervous system development | regulation of angiotensin-activated signaling pathway | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein localization to endosome | microtubule-based process | cellular process | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | neuron development | macromolecule localization | microtubule organizing center organization | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of myosin-light-chain-phosphatase activity | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | interspecies interaction between organisms | regulation of angiogenesis | regulation of cellular process | cellular response to lipid | regulation of metabolic process | regulation of bicellular tight junction assembly | cortical actin cytoskeleton organization | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | epithelium development | smooth muscle contraction | cellular component organization | viral life cycle | response to transforming growth factor beta | positive regulation of epithelial cell migration | muscle contraction | regulation of vasculature development | response to stimulus | peptidyl-threonine phosphorylation | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | regulation of centrosome cycle | embryonic epithelial tube formation | positive regulation of protein metabolic process | positive regulation of peptidase activity | positive regulation of cellular protein localization | positive regulation of actin filament bundle assembly | negative regulation of angiogenesis | tube morphogenesis | response to peptide | regulation of epithelial cell differentiation | protein serine/threonine kinase activity | programmed cell death | epithelial tube formation | cellular localization | rhythmic process | positive regulation of proteolysis | extrinsic apoptotic signaling pathway via death domain receptors | cellular response to organic cyclic compound | negative regulation of metabolic process | protein modification process | embryo development | macromolecule modification | positive regulation of stress fiber assembly | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of phosphate metabolic process | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | regulation of actin filament organization | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | regulation of catalytic activity | regulation of actomyosin structure organization | regulation of phosphorylation | negative regulation of cellular protein localization | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | protein localization to plasma membrane | positive regulation of cell cycle | regulation of gene expression | protein localization to membrane | neural tube closure | positive regulation of centrosome duplication | response to ketone | response to lipid | cell cycle | regulation of epidermis development | cellular response to testosterone stimulus | viral genome replication | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of keratinocyte differentiation | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | neural tube formation | regulation of cellular component movement | positive regulation of hydrolase activity | regulation of endothelial cell migration | positive regulation of cell migration | neural tube development | regulation of cellular protein metabolic process | phosphorylation | positive regulation of endopeptidase activity | protein phosphorylation | regulation of amyloid precursor protein catabolic process | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | negative regulation of protein dephosphorylation | chordate embryonic development | cell communication | regulation of cellular metabolic process | response to testosterone | regulation of establishment of endothelial barrier | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | viral process | apoptotic signaling pathway | embryonic morphogenesis | regulation of microtubule-based process | positive regulation of molecular function | response to angiotensin | neuron differentiation | regulation of centrosome duplication | negative regulation of bicellular tight junction assembly | protein metabolic process | centrosome duplication | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | response to organic substance | tissue morphogenesis | centrosome cycle | Rho protein signal transduction | regulation of protein dephosphorylation | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of connective tissue replacement | cell projection organization | metabolic process | positive regulation of supramolecular fiber organization | cellular protein localization | regulation of tissue remodeling | morphogenesis of embryonic epithelium | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of myosin-light-chain-phosphatase activity | negative regulation of cellular protein metabolic process | Rho-dependent protein serine/threonine kinase activity | regulation of phosphate metabolic process | cytoskeleton organization | positive regulation of endothelial cell migration | positive regulation of MAPK cascade | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | regulation of stress fiber assembly | negative regulation of protein metabolic process | regulation of epithelial cell migration | regulation of cell communication | negative regulation of molecular function | signaling | response to organic cyclic compound | regulation of amyloid-beta formation | cell development | I-kappaB kinase/NF-kappaB signaling | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | negative regulation of phosphoprotein phosphatase activity | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | regulation of actin filament bundle assembly | positive regulation of tissue remodeling | regulation of circadian rhythm | dendrite development | regulation of developmental process | regulation of G-protein coupled receptor protein signaling pathway | regulation of phosphoprotein phosphatase activity | kinase activity | developmental process | organelle organization | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | cortical cytoskeleton organization | tube development | regulation of cell junction assembly | negative regulation of vasculature development | Ras protein signal transduction | regulation of endothelial cell differentiation | response to organonitrogen compound | tube closure | negative regulation of dephosphorylation | negative regulation of hydrolase activity | tube formation | positive regulation of metabolic process | regulation of actin filament-based process | cellular metabolic process | positive regulation of amyloid-beta formation | cellular response to organic substance | regulation of protein localization | positive regulation of cell motility | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of epidermal cell differentiation | regulation of cytoskeleton organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | viral RNA genome replication | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | microtubule organizing center | cell | ribonucleoprotein granule | spindle pole centrosome | cytoplasm | spindle | intracellular organelle | centrosome | protein-containing complex | plasma membrane | ribonucleoprotein complex | microtubule cytoskeleton | spindle pole | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | cell periphery | cytosol | cytoskeleton | intracellular | membrane
